Role and New Insights of Pirfenidone in Fibrotic Diseases.
Role and New Insights of Pirfenidone in Fibrotic Diseases.
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DOI：
10.7150/ijms.11579
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发表时间：
2015
影响因子：
3.6
通讯作者：
Armendariz-Borunda J
中科院分区：
文献类型：
--
作者：
Lopez-de la Mora DA;Sanchez-Roque C;Montoya-Buelna M;Sanchez-Enriquez S;Lucano-Landeros S;Macias-Barragan J;Armendariz-Borunda J
吡非尼酮（PFD）是一种非肽类合成分子，作为一种广谱抗纤维化药物，具有降低TGF-β1、TNF-α、PDGF和COL 1A 1表达的能力，这与预防或消除多个器官中瘢痕组织的过度沉积高度相关。基础和临床证据表明，PFD可以安全地减缓或抑制组织损伤后进行性纤维化肿胀。此外，许多证据表明，这种分子将在治疗其他炎症性疾病方面具有积极作用。本文综述了目前PFD用于治疗多种疾病的研究，主要关注与改善炎症和纤维化相关的结果。因此，本综述的主要目标是关注PFD功效的新发现，而不是深入分子的化学方面。
Pirfenidone (PFD) is a non-peptide synthetic molecule issued as a broad-spectrum anti-fibrotic drug with the ability to decrease TGF-β1, TNF-α, PDGF and COL1A1 expression, which is highly related to prevent or remove excessive deposition of scar tissue in several organs. Basic and clinical evidence suggests that PFD may safely slow or inhibit the progressive fibrosis swelling after tissue injuries. Furthermore, a number of evidence suggests that this molecule will have positive effects in the treatment of other inflammatory diseases. This review contains current research in which PFD has been used as the treatment of several diseases, and focus mainly in the outcomes related to improve inflammation and fibrogenesis. Therefore, the main goal of this review is to focus on the novel findings of PFD efficacy rather than deepen in the chemical aspects of the molecule.