Radiomics Analysis of DTI Data to Assess Vision Outcome After Intravenous Methylprednisolone Therapy in Neuromyelitis Optic Neuritis.
Radiomics Analysis of DTI Data to Assess Vision Outcome After Intravenous Methylprednisolone Therapy in Neuromyelitis Optic Neuritis.
复制标题
DTI 数据的放射组学分析可评估神经脊髓炎视神经炎静脉注射甲泼尼龙治疗后的视力结果。
DOI：
10.1002/jmri.26326
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发表时间：
2018
影响因子：
4.4
通讯作者：
Ma Lin
中科院分区：
文献类型：
--
作者：
Tian Yuan;Liu Zhenyu;Tang Zhenchao;Li Mingge;Lou Xin;Dong Enqing;Liu Gang;Wang Yulin;Wang Yan;Bian Xiangbin;Wei Shihui;Tian Jie;Ma Lin
背景视神经肌炎-视神经炎（NMO-ON）患者常规使用静脉内甲泼尼龙（IVMP）治疗。对IVMP治疗无效的患者，应采用更有效但更积极的血浆置换（PE）治疗替代IVMP作为一线治疗。目的通过全脑弥散张量成像（DTI）数据的放射组学分析，评估NMO-ON患者IVMP治疗后的视力结局。研究类型回顾性。DTI图像由单次激发回波平面图像序列采集; T1图像由3D快速扰相梯度回波（3D-FSPGR）MRI采集。评估从DTI数据中提取了200个DTI测量值，并将其用作特征，以构建IVMP后NMO-ON患者视觉结果的放射组学评估模型。通过受试者工作特征曲线下面积（AUC）、分类准确度（ACC）、敏感性、特异性以及阳性和阴性预测值（PPV和NPV）评价评估性能。统计学检验采用Pearson相关、斯皮尔曼秩相关和单因素方差分析等方法，对所选DTI指标与NMO-ON患者的临床视觉特征之间的关系进行了研究。（P= 0.002），AUC为0.7931，灵敏度为0.6207，特异度为0.8571，PPV为0.8182，NPV为0.6857，用于评估IVMP治疗后NMO-ON患者的视力结局。选定的DTI测量显示与视觉相关区域、运动相关区域和胼胝体的白色物质束中的视觉结果相关的白色物质损伤。发现白色损害与病程和视神经病变长度显著相关。Data ConclusionRadiomics分析DTI数据在评估IVMP治疗后NMO-ON患者的视力结果方面具有很大的潜力。Magn. Reson.成像2019;49：1365-1373.
BackgroundNeuromyelitis optica‐optic neuritis (NMO‐ON) patients are routinely treated with intravenous methylprednisolone (IVMP). For the patients nonresponsive to IVMP, more effective but aggressive therapy of plasma exchange (PE) should be employed instead of IVMP in the first line.PurposeTo assess the visual outcomes of NMO‐ON patients after IVMP by radiomics analysis of whole brain diffusion tensor imaging (DTI) data.Study TypeRetrospective.PopulationIn all, 57 NMO‐ON patients receiving IVMP therapy for 3 days.Field Strength/Sequence3.0T; DTI images acquired by a single‐shot echo planar image sequence; T1images acquired by 3D fast spoiled gradient echo (3D‐FSPGR) MRI.AssessmentIn all, 200 DTI measures were extracted from the DTI data and employed as features to construct a radiomics assessment model for visual outcomes of NMO‐ON patients after IVMP. The assessment performance was evaluated by area under the receiver operating characteristic curve (AUC), classification accuracy (ACC), sensitivity, specificity, and positive and negative predicted values (PPV and NPV). The selected DTI measures would reveal the white matter impairments related to visual recovery of NMO‐ON patients.Statistical TestsThe relationship between the selected DTI measures and the clinical visual characteristics were investigated by Pearson correlation, Spearman's rank correlation, and one‐way analysis of variance analysis.ResultsThe radiomics model obtained an ACC of 73.68% (P= 0.002), AUC of 0.7931, sensitivity of 0.6207, specificity of 0.8571, PPV of 0.8182, and NPV of 0.6857 in assessing visual outcomes of the NMO‐ON patients after IVMP treatment. The selected DTI measures revealed white matter impairments related to the visual outcomes in the white matter tracts of vision‐relevant regions, motor‐related regions, and corpus callosum. The white matter impairments were found significantly correlated with the disease duration and the length of lesions in the optic nerve.Data ConclusionRadiomics analysis of DTI data has great potential in assessing visual outcomes of NMO‐ON patients after IVMP therapy.Level of Evidence:2Technical Efficacy:Stage 4J. Magn. Reson. Imaging 2019;49:1365–1373.