A repressor complex governs the integration of flowering signals in Arabidopsis
A repressor complex governs the integration of flowering signals in Arabidopsis
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DOI：
10.1016/j.devcel.2008.05.002
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发表时间：
2008-07-01
影响因子：
11.8
通讯作者：
Yu, Hao
中科院分区：
文献类型：
--
作者：
Li, Dan;Liu, Chang;Yu, Hao
多个遗传途径响应发育线索和环境信号，通过调节多个花途径整合子来促进花转变。这些包括FLOW LOCUS T（FT）和SUPPLOR OF OVEREXPRESSION OF CONSTANS 1（SOC1）。我们发现，开花抑制短营养期（SVP）是由自主，热感觉，赤霉素途径控制，并直接抑制SOC1转录在茎尖和叶。此外，叶中FT的表达也受到SVP的调节。SVP蛋白与SOC1和FT的启动子区结合，另一种有效的阻遏物FLOWERLOCUS C（FLC）结合在那里。在营养生长过程中，SVP与FLC在体内一致地相互作用，并且它们的功能是相互依赖的。我们的研究结果表明，SVP是开花调节网络的另一个中心调节因子，并且由各种开花遗传途径介导的SVP和FLC之间的相互作用控制着开花信号的整合。
Multiple genetic pathways act in response to developmental cues and environmental signals to promote the floral transition, by regulating several floral pathway integrators. These include FLOWERING LOCUS T (FT) and SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1). We show that the flowering repressor SHORT VEGETATIVE PHASE (SVP) is controlled by the autonomous, thermo-sensory, and gibberellin pathways, and directly represses SOC1 transcription in the shoot apex and leaf. Moreover, FT expression in the leaf is also modulated by SVP. SVP protein associates with the promoter regions of SOC1 and FT, where another potent repressor FLOWERING LOCUS C (FLC) binds. SVP consistently interacts with FLC in vivo during vegetative growth and their function is mutually dependent. Our findings suggest that SVP is another central regulator of the flowering regulatory network, and that the interaction between SVP and FLC mediated by various flowering genetic pathways governs the integration of flowering signals.