Race and ethnicity correlate with survival in patients with gastric adenocarcinoma
Race and ethnicity correlate with survival in patients with gastric adenocarcinoma
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DOI：
10.1093/annonc/mdp290
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发表时间：
2010-01-01
影响因子：
50.5
通讯作者：
Ellenhorn, J. D. I.
中科院分区：
文献类型：
--
作者：
Kim, J.;Sun, C. -L.;Ellenhorn, J. D. I.
患者和方法：从洛杉矶县癌症监测项目中确定了1988年至2006年在洛杉矶县接受治疗的胃腺癌患者。患者按种族和民族分为白色，亚洲，西班牙裔和Black.Results：在13 084例患者中，39%是白色，22%亚洲，28%西班牙裔，11%黑人和2%其他。亚裔患者的生存率高于白人、西班牙裔和黑人[中位生存期（MS）分别为16.3个月与8.4个月、8.7个月和7.9个月;对数秩P值< 0.001]。多变量考克斯回归分析显示，亚洲人的生存概率提高[风险比（HR）0.76，95%置信区间（CI）0.72-0.82; P < 0.001]。在接受治愈性手术的患者中，亚裔患者的生存率高于白人、西班牙裔和黑人（MS分别为32.7个月和18.8个月、19.9个月和18.9个月;对数秩P值< 0.001）。多变量考克斯回归分析显示亚洲人手术后生存率更高（HR 0.79，95%CI 0.71-0.88; P < 0.001）。结论：亚洲人胃腺癌患者在洛杉矶县有上级预后。这些结果证实了胃癌生存率在不同种族和民族之间的差异，独立于既定的临床和病理因素。
Patients and methods: Patients with gastric adenocarcinoma treated in Los Angeles County from 1988 to 2006 were identified from the Los Angeles County Cancer Surveillance Program. Patients were categorized by race and ethnicity as White, Asian, Hispanic and Black.Results: Of 13 084 patients, 39% were White, 22% Asian, 28% Hispanic, 11% Black and 2% other. Asian patients demonstrated higher survival than Whites, Hispanics and Blacks [median survival (MS) 16.3 versus 8.4, 8.7 and 7.9 months, respectively; log-rank P values < 0.001]. Multivariate Cox regression analysis showed that Asians had improved probability of survival [hazard ratio (HR) 0.76, 95% confidence interval (CI) 0.72-0.82; P < 0.001]. In patients who underwent curative-intent surgery, Asian patients demonstrated higher survival than Whites, Hispanics and Blacks (MS 32.7 versus 18.8, 19.9 and 18.9 months, respectively; log-rank P values < 0.001). Multivariate Cox regression analysis showed that Asians had improved probability of survival after surgery (HR 0.79, 95% CI 0.71-0.88; P < 0.001).Conclusions: Asians with gastric adenocarcinoma have superior outcomes in Los Angeles County. These outcomes verify disparities in gastric cancer survival among different races and ethnicities independent of established clinical and pathologic factors.