CORONARY VASOMOTOR RESPONSE TO ACETYLCHOLINE RELATES TO RISK-FACTORS FOR CORONARY-ARTERY DISEASE
CORONARY VASOMOTOR RESPONSE TO ACETYLCHOLINE RELATES TO RISK-FACTORS FOR CORONARY-ARTERY DISEASE
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DOI：
10.1161/01.cir.81.2.491
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发表时间：
1990-02-01
期刊：
影响因子：
37.8
通讯作者：
GANZ, P
中科院分区：
文献类型：
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作者：
VITA, JA;TREASURE, CB;GANZ, P
在动物中，乙酰胆碱会扩张正常动脉，并在高胆固醇血症、高血压或动脉粥样硬化的情况下产生血管收缩，反映内皮细胞功能障碍。据报道，在血管造影冠状动脉平滑的患者中，乙酰胆碱可产生血管舒张和收缩作用。为了验证乙酰胆碱反应与冠状动脉疾病危险因素相关的假设，将 10-8 至 10-6 M 乙酰胆碱注入左冠状动脉前降支或回旋支，并通过血管造影对 34 名冠状动脉平滑的患者进行定量血管造影来评估直径变化。在乙酰胆碱峰值剂量下，乙酰胆碱反应范围为+37%（扩张）至-53%（收缩）。所有冠状动脉均因硝酸甘油而扩张（26.+-.17%），表明对乙酰胆碱有收缩反应的患者内皮功能异常。通过多元逐步回归分析，血清胆固醇（p
In animals, acetylcholine dilates normal arteries and produces vasoconstriction in the presence of hypercholesterolemia, hypertension, or atherosclerosis, reflecting endothelial cell dysfunction. In patients with angiographically smooth coronary arteries, acetylcholine has been reported to produce both vasodilation and constriction. To test the hypothesis that the acetylcholine response relates to risk factors for coronary artery disease, acetylcholine 10-8 to 10-6 M was infused into the left anterior descending or circumflex coronary artery, and diameter changes were assessed with quantitative angiography in 34 patients with angiographically smooth coronary arteries. The acetylcholine response ranged from +37% (dilation) to -53% (constriction) at the peak acetylcholine dose. All coronary arteries dilated in response to nitroglycerin (26.+-.17%), suggesting an abnormality of endothelial function in the patients with a constrictor response to acetylcholine. By multiple stepwise regression analysis, serum cholesterol (p