REDUCED BRAIN N-ACETYLASPARTATE SUGGESTS NEURONAL LOSS IN COGNITIVELY IMPAIRED HUMAN-IMMUNODEFICIENCY-VIRUS-SEROPOSITIVE INDIVIDUALS - INVIVO H-1 MAGNETIC-RESONANCE SPECTROSCOPIC IMAGING
REDUCED BRAIN N-ACETYLASPARTATE SUGGESTS NEURONAL LOSS IN COGNITIVELY IMPAIRED HUMAN-IMMUNODEFICIENCY-VIRUS-SEROPOSITIVE INDIVIDUALS - INVIVO H-1 MAGNETIC-RESONANCE SPECTROSCOPIC IMAGING
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DOI：
10.1212/wnl.43.3_part_1.509
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发表时间：
1993-03-01
期刊：
影响因子：
9.9
通讯作者：
FEIN, G
中科院分区：
文献类型：
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作者：
MEYERHOFF, DJ;MACKAY, S;FEIN, G
我们使用磁共振成像（MRI）和水抑制质子磁共振波谱成像研究人类免疫缺陷病毒（HIV）感染对10名因HIV所致认知障碍的患者和7名正常对照者大脑的影响。H-1光谱从9个2.5毫升的体积在半卵圆中心和近中皮质显示显着减少N-乙酰天冬氨酸（NAA）相对于胆碱和肌酸在认知功能受损的HIV感染的受试者。这种减少是由于这些患者中NAA的非局限性减少，其中只有2例患者在MRI上有中度萎缩和白色信号高信号。由于NAA是一种假定的神经元标记物，因此研究结果表明HIV感染早期的神经元损伤在标准MRI上并不明显，并且与神经病理学上已知的神经元损失一致。
We used magnetic resonance imaging (MRI) and water-suppressed proton magnetic resonance spectroscopic imaging to study the effects of human immunodeficiency virus (HIV) infection on the brains of 10 individuals with cognitive impairment due to HIV and seven normal controls. H-1 spectra from nine 2.5-ml volumes in the centrum semiovale and the mesial cortex showed significantly reduced N-acetylaspartate (NAA) relative to choline and creatine in the cognitively impaired HIV-infected subjects. This reduction was due to a nonlocalized decrease of NAA in these patients, only two of whom had moderate atrophy and white matter signal hyperintensities on MRI. Since NAA is a putative neuronal marker, the findings suggest neuronal damage in early stages of HIV infection that is not evident on standard MRI and are consistent with the neuropathologically known neuronal loss.