Permeability of tritiated water through human cervical and vaginal tissue
Permeability of tritiated water through human cervical and vaginal tissue
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DOI：
10.1002/jps.20107
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发表时间：
2004-08-01
影响因子：
3.8
通讯作者：
Rohan, LC
中科院分区：
文献类型：
--
作者：
Sassi, AB;McCullough, D;Rohan, LC
人类免疫缺陷病毒感染在妇女中的发病率增加，这表明迫切需要开发一种由女性控制的方法，以防止感染人类免疫缺陷病毒和其他性传播疾病。女性会在性交前在阴道内使用该产品。开发这种产品需要更好地了解这种产品将接触到的组织的渗透性特征。然而，在这一领域进行的研究有限。本研究对新鲜人宫颈和阴道组织的透水性进行了评价。新鲜人宫颈组织的平均表观渗透系数为8×10(-5)cm/S，新鲜人阴道组织的表观渗透系数为7×10(-5)cm/S。考虑到从手术标本中获取宫颈和阴道组织缺乏规律性，还进行了额外的测试，以评估冷冻对氚水渗透性的影响。当比较新鲜组织和冷冻组织时，所获得的渗透率值在统计学上没有显著差异。(C)2004年Wiley-Liss，Inc.
The increased incidence of human immunodeficiency virus infection in women has identified an urgent need to develop a female-controlled method to prevent acquisition of human immunodeficiency virus and other sexually transmitted diseases. Women would apply the product intravaginally before intercourse. Development of such a product requires a better understanding of the permeability characteristics of the tissues with which such products would come into contact. However, limited studies have been performed in this area. In the present study, water permeability of fresh human cervical and vaginal tissue was evaluated. The average apparent permeability coefficient was found to be 8 x 10(-5) cm/s for fresh human cervical tissue and 7 x 10(-5) cm/s for fresh human vaginal tissue. Considering the lack of regularity in obtaining cervical and vaginal tissue from surgical specimens, additional tests were performed to evaluate the effect of freezing on tritiated water permeability. No statistically significant differences were observed in the permeability values obtained when comparing fresh versus frozen tissues. (C) 2004Wiley-Liss, Inc.