Ethanol inhibition of phagocytosis and superoxide anion production by microglia
Ethanol inhibition of phagocytosis and superoxide anion production by microglia
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DOI：
10.1016/s0741-8329(97)00129-8
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发表时间：
1998-05-01
期刊：
影响因子：
2.3
通讯作者：
Baker, RC
中科院分区：
文献类型：
--
作者：
Aroor, AR;Baker, RC
乙醇消耗与异常免疫应答相关，导致对感染的易感性增加，包括中枢神经系统的机会性感染。我们研究了慢性乙醇处理对小胶质细胞吞噬作用和超氧阴离子产生的影响。吞噬放射性标记的调理E.用乙醇处理小胶质细胞显著抑制了大肠杆菌的表达。无刺激的超氧阴离子的合成没有改变乙醇处理的小胶质细胞，但乙醇处理有效地抑制佛波醇-12肉豆蔻酸酯-13乙酸酯刺激的小胶质细胞超氧阴离子的产生。结果表明，乙醇抑制小胶质细胞功能可能在增加中枢神经系统感染的易感性中发挥作用，特别是在免疫功能低下的受试者中。(C)1998年爱思唯尔科学公司
Ethanol consumption has been associated with aberrant immune responses resulting in increased susceptibility to infection including opportunistic infections of the central nervous system. We have investigated the effects of chronic ethanol treatment on phagocytosis and production of superoxide anion by microglia. Phagocytosis of radiolabeled opsonized E. coli was markedly suppressed by treating microglia with ethanol. The unstimulated synthesis of super-oxide anion was not altered by ethanol treatment of microglia, but ethanol treatment effectively suppressed phorbol-12 myristate-13 acetate-stimulated microglia superoxide anion production. The results indicate that ethanol inhibition of microglia function may play a role in increased susceptibility for central nervous system infections, particularly in immunocompromised subjects. (C) 1998 Elsevier Science Inc.