Detailed analysis of the mRNAs mapping in the short unique region of herpes simplex virus type 1.
Detailed analysis of the mRNAs mapping in the short unique region of herpes simplex virus type 1.
复制标题
1 型单纯疱疹病毒短独特区域 mRNA 定位的详细分析。
作者：
F. Rixon;D. McGeoch
我们分析了单纯疱疹病毒1型（HSV-1）基因组短独特（US）区域内的mrna。US全长12979个碱基对(1)，被广泛转录，约94%的总序列存在于细胞质mrna中，79%的总序列被认为是蛋白质编码。在这个区域有几个重叠功能和多重使用DNA序列的例子。US包含12个基因(1)，表达为13个mrna。这些mrna中的两个被认为来自同一个基因，因为它们只是在其5'端位置上略有不同，并且可能指定相同的多肽。13个mrna中的11个被排列成四个嵌套的家族，具有独特的5‘端和共同的3’共端。另外两个mrna有独特的5‘和3’端。
We have analysed the mRNAs which map within the short unique (US) region of the herpes simplex virus type 1 (HSV-1) genome. US has a total length of 12979 base pairs (1) and is extensively transcribed with approximately 94% of the total sequence present in cytoplasmic mRNAs and 79% of the total sequence considered to be protein coding. There are several examples of overlapping functions and multiple use of DNA sequence within this region. US contains 12 genes (1) which are expressed as 13 mRNAs. Two of these mRNAs are thought to arise from the same gene since they differ only slightly in the positions of their 5' ends and probably specify the same polypeptide. 11 of the 13 mRNAs are arranged into four nested families with unique 5' ends and common 3' co-termini. The other two mRNAs have unique 5' and 3' ends.