Sustained curcumin release from PLGA microspheres improves bone formation under diabetic conditions by inhibiting the reactive oxygen species production.
Sustained curcumin release from PLGA microspheres improves bone formation under diabetic conditions by inhibiting the reactive oxygen species production.
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DOI：
10.2147/dddt.s154334
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Zhang ZZ
中科院分区：
文献类型：
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作者：
Li Y;Zhang ZZ
2型糖尿病引起的活性氧产生过多会破坏正常的骨代谢，严重损害骨再生。在本研究中，将姜黄素（Cur）负载微球掺入鱼胶原纳米羟基磷灰石支架中，通过抑制活性氧的产生来促进糖尿病患者的骨修复。药物释放动力学研究表明，复合支架的释放时间长达30天。支架持续释放姜黄素可显著抑制糖尿病血清引起的间充质干细胞活性氧过量产生。此外，cu负载支架还能显著缓解糖尿病血清对间充质干细胞增殖、迁移和成骨分化的负面影响。当植入2型糖尿病大鼠骨缺损时，与纯支架相比，负载cu的支架也显示出更大的骨形成能力。本研究结果表明，这种新型的控制Cur释放系统可能为改善2型糖尿病患者的骨再生提供了一条有希望的途径。
Excessive reactive oxygen species production caused by type 2 diabetes conditions can disrupt normal bone metabolism and greatly impair bone regeneration. In the present study, curcumin (Cur)-loaded microspheres were incorporated into a fish collagen nano-hydroxyapatite scaffold to promote bone repair under diabetic conditions by inhibiting the reactive oxygen species production. The drug release kinetic study showed that the Cur release from the composite scaffolds lasted up to 30 days. The sustained curcumin release from the scaffold significantly inhibited the overproduction of reactive oxygen species in mesenchymal stem cells caused by diabetic serum. Moreover, the Cur-loaded scaffold also remarkedly alleviated the negative effects of diabetic serum on the proliferation, migration, and osteogenic differentiation of mesenchymal stem cells. When implanted into bone defects in type 2 diabetic rats, the Cur-loaded scaffold also showed a greater bone formation capability compared to the pure scaffold. The results of this study suggested that the novel controlled Cur release system may provide a promising route to improve bone regeneration in type 2 diabetic patients.