Full-brain coverage and high-resolution Imaging capabilities of passband b-SSFP fMRI at 3T
Full-brain coverage and high-resolution Imaging capabilities of passband b-SSFP fMRI at 3T
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DOI：
10.1002/mrm.21576
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发表时间：
2008-05-01
影响因子：
3.3
通讯作者：
Pauly, John M.
中科院分区：
文献类型：
--
作者：
Lee, Jin Hyung;Dumoulin, Serge O.;Pauly, John M.
通带平衡稳态自由旋进（b-SSFP）fMRI是最近发展的一种方法，其利用b-SSFP非共振响应的通带（平坦部分）来测量由神经元活动增加后组织氧合变化引起的MR信号变化。b-SSFP的快速重新聚焦和短读出持续时间，结合b-SSFP非共振光谱的相对较大的平坦部分，允许仅用两次采集实现无失真的全脑覆盖。这允许高分辨率功能成像，而没有在常规高分辨率功能图像中经常遇到的空间失真。最后，b-SSFP采集的3D成像兼容性允许各向同性体素大小的高分辨率采集。在这项研究中，我们解决了一些主要的技术问题，在获得通带bSSFP为基础的功能脑图像与实际的成像参数，并通过屏气和视野映射实验证明的优势。
Passband balanced-steady-state free precession (b-SSFP) fMRI is a recently developed method that utilizes the passband (flat portion) of the b-SSFP off-resonance response to measure MR signal changes elicited by changes in tissue oxygenation following increases in neuronal activity. Rapid refocusing and short readout durations of b-SSFP, combined with the relatively large flat portion of the b-SSFP off-resonance spectrum allows distortion-free full-brain coverage with only two acquisitions. This allows for high-resolution functional imaging, without the spatial distortion frequently encountered in conventional high-resolution functional images. Finally, the 3D imaging compatibility of the b-SSFP acquisitions permits isotropic-voxel-size high-resolution acquisitions. In this study we address some of the major technical issues involved in obtaining passband bSSFP-based functional brain images with practical imaging parameters and demonstrate the advantages through breathholding and visual field mapping experiments.