THE EFFECT OF POLY-UNSATURATED PHOSPHATIDYLCHOLINE ON PLASMA-LIPIDS AND FECAL STEROL EXCRETION
THE EFFECT OF POLY-UNSATURATED PHOSPHATIDYLCHOLINE ON PLASMA-LIPIDS AND FECAL STEROL EXCRETION
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DOI：
10.1016/0021-9150(80)90201-4
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发表时间：
1980-01-01
期刊：
影响因子：
5.3
通讯作者：
SCHETTLER, G
中科院分区：
文献类型：
--
作者：
GRETEN, H;RAETZER, H;SCHETTLER, G
高多不饱和磷脂酰胆碱（PC）口服给家族性高胆固醇血症患者和正常对照组。分析血浆脂质和脂蛋白组成、粪便固醇排泄和胆汁脂质组成。两种饮食方案，含有类似的热量，胆固醇和多不饱和脂肪酸，以评估磷酸胆碱的具体效果。未观察到血浆脂质或脂蛋白浓度变化。当PC添加到饮食中时，所有受试者的粪便固醇排泄量均大幅增加。胆汁中的胆汁酸、磷脂和胆固醇含量没有变化。[多不饱和磷脂酰胆碱或必需磷脂被广泛用作治疗动脉血管疾病的治疗剂]。
Highly polyunsaturated phosphatidylcholine (PC) was orally administered to patients with familial hypercholesterolemia and normal controls. Plasma lipid and lipoprotein composition, fecal sterol excretion and bile lipid composition were analyzed. Two dietary regimens were given containing similar amounts of calories, cholesterol and polyunsaturated fatty acids to evaluate the specific effect of phosphorylcholine. No change in plasma lipid or lipoprotein concentration was observed. Fecal sterol excretion was substantially increased in all subjects when PC was added to the diet. Bile acids, phospholipid and cholesterol content in bile did not vary. [Polyunsaturated phosphatidylcholine or essential phospholipids are extensively applied as a therapeutic agent in the treatment of arteriosclerotic vascular disease.].