The study on the susceptible gene of isoniazid and rifampicin-induced hepatotoxicity of pulmonary tuberculosis patients
The study on the susceptible gene of isoniazid and rifampicin-induced hepatotoxicity of pulmonary tuberculosis patients
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发表时间：
2004
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通讯作者：
Pei-Yong Ning
中科院分区：
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作者：
Pei-Yong Ning
目的：探讨肺结核患者对异烟肼和利福平肝毒性的易感性与N-乙酰转移酶2(NAT2)基因分型的关系。方法：采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法对67例肝功能正常或异常的肺结核患者的NAT2基因进行分析。结果：病例组和对照组的NAT2基因857位密码子突变频率分别为20.3%和7.1%，差异有统计学意义。结论：Nat2基因857位密码子突变可能是肺结核患者肝功能异常的易感基因之一。
Objective:To investigate the relationship between the susceptibility of isoniazid and rifampicin-induced hepatotoxicity and the N-acetyltransferase 2(NAT2) genotype in the tuberculosis patients.Methods:NAT2 gene was analyzed in 67 pulmonary tuberculosis patients who had normal or abnormal hepatic function by PCR-RFLP.Results:The frequencies of NAT2 gene mutation at codon 857 in patient group and control group were 20.3% and7.1%,respectively,there were significant difference. Conclusion:NAT2 gene mutation at codon 857 might be one of susceptible genotype in the tuberculosis patients whose hepatic functions were abnormal.