Cochlear neurons: frequency selectivity altered by conductance change in scala tympani.
Cochlear neurons: frequency selectivity altered by conductance change in scala tympani.
复制标题
耳蜗神经元：频率选择性因鼓阶电导变化而改变。
DOI：
10.1121/1.380546
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
G. K. Yates
中科院分区：
文献类型：
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作者：
J. R. Johnstone;B. M. Johnstone;G. K. Yates
最近有报道称，当豚鼠耳蜗中耳膜周围淋巴被切除时，听神经神经节细胞的调谐曲线受到严重影响。这表明在类似条件下基底膜振动的测量也可能受到影响，不能代表正常耳蜗。因此，神经调节曲线和基底膜调节曲线之间存在的差异可以解释。我们已经证实了这种作用在神经元上的存在，但我们提出了两种证据，证明它不是由于基底膜的改变。首先，必须切除的淋巴管的数量大于常规机械测量切除的淋巴管的数量。第二，用等渗蔗糖填充scala也会产生同样的变化。我们的结论是，切除淋巴周围通过改变耳蜗的电特性来影响听觉神经元，基底膜和神经节细胞的调谐曲线之间的差异不是由于基底膜的变化。
It has recently been reported that when perilymph is removed from scala tympani of guinea pig cochlea, the tuning curves of auditory nerve ganglion cells are seriously affected. This suggests that measurements of basilar membrane vibration under similar conditions may also be affected and not representative of the normal cochlea. Hence the discrepancy known to exist between neural tuning curves and basilar membrane tuning curves could be explained. We have confirmed the existence of this effect on neurons, but we present two kinds of evidence that it is not due to a basilar membrane change. First, the amount of perilymph which must be removed is greater than that routinely removed for mechanical measurements. Second, filling the scala with isotonic sucrose produces the same change. We conclude that removal of perilymph affects auditory neurons by changing the electrical properties of the cochlea and that the difference between tuning curves of the basilar membrane and ganglion cells is due not to a basila...