SELECTIVE BRAIN DOPAMINE DEPLETION IN DEVELOPING RATS - EXPERIMENTAL-MODEL OF MINIMAL BRAIN-DYSFUNCTION
SELECTIVE BRAIN DOPAMINE DEPLETION IN DEVELOPING RATS - EXPERIMENTAL-MODEL OF MINIMAL BRAIN-DYSFUNCTION
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DOI：
10.1126/science.942800
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发表时间：
1976-01-01
期刊：
影响因子：
56.9
通讯作者：
KLOPPER, JH
中科院分区：
文献类型：
--
作者：
SHAYWITZ, BA;YAGER, RD;KLOPPER, JH
给新生大鼠施用6-羟基多巴胺可导致脑多巴胺快速而深刻的耗竭。在12至22日龄之间，接受治疗的动物的总活动显著大于对照组，但随后下降，这种活动模式与受影响儿童中观察到的活动模式相似。这表明在轻微脑功能障碍的发病机制中脑多巴胺的功能性缺乏。
Administration of 6-hydroxydopamine to neonatal rats produces a rapid and profound depletion of brain dopamine. Total activity of treated animals is significantly greater than that of controls between 12 and 22 days of age, but then declines, an activity pattern similar to that seen in affected children. This suggests a functional deficiency of brain dopamine in the pathogenesis of minimal brain dysfunction.