Antigen-Nonspecific Recruitment of Th2 Cells to the Lung as a Mechanism for Viral Infection-Induced Allergic Asthma1
Antigen-Nonspecific Recruitment of Th2 Cells to the Lung as a Mechanism for Viral Infection-Induced Allergic Asthma1
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Th2 细胞抗原非特异性募集至肺部作为病毒感染引起的过敏性哮喘的机制1
作者：
R. Stephens;D. Randolph;Guangming Huang;M. Holtzman;D. Chaplin
呼吸道病毒感染已被证明会引发哮喘的恶化;然而，病毒性Th 1型炎症加剧过敏性Th 2型疾病的机制仍不清楚。我们以前已经表明，虽然过继转移的Th 2细胞是无效的招募到肺中的抗原，共转移的Th 1细胞可以增加积累的Th 2细胞。在这项研究中，我们表明，呼吸道病毒感染增加募集的静止的Th 2细胞特异性的卵清蛋白，即使在没有卵清蛋白的挑战。这些发现表明，Th 1型炎症增强过敏的机制是通过对募集的影响。为了研究Th 1细胞的抗原特异性在增强Th 2细胞募集中的作用，并确定病毒诱导的OVA特异性Th 2细胞募集是否涉及对不同抗原特异性的Th 1细胞，我们测试了鸡蛋溶菌酶特异性Th 1细胞是否可以与OVA特异性Th 2细胞协同作用。接受过继性转移的Th 1细胞加Th 2细胞的小鼠的攻击诱导了肺中炎性趋化因子的表达，并增加了Th 2细胞的募集和活化，导致嗜酸性粒细胞募集，即使在没有Th 2 Ag的攻击的情况下。有趣的是，由于IL-5支持嗜酸性粒细胞增多，在缺乏特异性Ag的情况下，用新鲜APC培养静息Th 2细胞诱导IL-5的产生。因此，Th 1细胞的Ag特异性活化增强肺的募集潜力，导致Th 2细胞的募集和活化。这意味着过敏个体中的循环Th 2细胞可以响应感染或炎症进入肺部，并被激活以引发过敏。
Respiratory viral infections have been shown to trigger exacerbations of asthma; however, the mechanism by which viral Th1-type inflammation exacerbates an allergic Th2-type disease remains unclear. We have previously shown that although adoptively transferred Th2 cells are inefficiently recruited to the lung in response to Ag, cotransfer of Th1 cells can increase accumulation of Th2 cells. In this study, we show that respiratory viral infection increases recruitment of resting Th2 cells specific for OVA even in the absence of OVA challenge. These findings suggest that the mechanism by which Th1-type inflammation enhances allergy is via an effect on recruitment. To study the role of the antigenic specificity of Th1 cells in the enhancement of Th2 cell recruitment and to determine whether virus-induced recruitment of OVA-specific Th2 cells may involve Th1 cells specific to a different Ag, we tested whether hen egg lysozyme-specific Th1 cells could synergize with OVA-specific Th2 cells. Challenge of mice that had received adoptively transferred Th1 cells plus Th2 cells induced the expression of inflammatory chemokines in the lung and increased both recruitment and activation of Th2 cells, leading to eosinophil recruitment, even in the absence of challenge with the Th2 Ag. Interestingly, as IL-5 supports eosinophilia, culture of resting Th2 cells with fresh APC induced production of IL-5 in the absence of specific Ag. Thus, Ag-specific activation of Th1 cells enhances the recruitment potential of the lung leading to recruitment and activation of Th2 cells. This implies that circulating Th2 cells in allergic individuals could enter the lungs in response to infection or inflammation and become activated to trigger allergy.
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影响因子：
15.9
作者：
Schwarze, J;Hamelmann, E;Gelfand, EW
通讯作者：
Gelfand, EW
胰岛特异性 Th1 细胞（而非 Th2 细胞）分泌多种趋化因子，促进自身免疫性糖尿病的快速诱导。
DOI：
--
发表时间：
1999
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bradley,LM;Asensio,VC;Schioetz,LK;Harbertson,J;Krahl,T;Patstone,G;Woolf,N;Campbell,IL;Sarvetnick,N
通讯作者：
Sarvetnick,N
使用类似肽将 T 辅助细胞 1 克隆细胞溶解与增殖和淋巴因子产生分离。
DOI：
--
发表时间：
1993
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Evavold,BD;Sloan-Lancaster,J;Hsu,BL;Allen,PM
通讯作者：
Allen,PM
影响因子：
4.4
作者：
S. Swain;A. Weinberg;M. English;G. Huston
通讯作者：
S. Swain;A. Weinberg;M. English;G. Huston
在哮喘小鼠模型中通过被动转移过敏原特异性 Th1 和 Th2 细胞来调节气道炎症。
DOI：
--
发表时间：
1999
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Randolph,DA;Carruthers,CJ;Szabo,SJ;Murphy,KM;Chaplin,DD
通讯作者：
Chaplin,DD