CD28(-) T cells: their role in the age-associated decline of immune function.
CD28(-) T cells: their role in the age-associated decline of immune function.
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DOI：
10.1016/j.it.2009.03.013
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发表时间：
2009-07
影响因子：
16.8
通讯作者：
Goronzy J
中科院分区：
文献类型：
--
作者：
Weng NP;Akbar AN;Goronzy J
CD28− T细胞的积累，特别是在CD8亚群中，是与人类衰老相关的T细胞稳态和功能中最显著的变化之一。CD28是一种主要的共刺激受体，负责最佳抗原介导的T细胞活化、增殖和T细胞存活。CD28− T细胞表现出抗原受体多样性降低，抗原诱导增殖缺陷，复制寿命缩短，同时表现出增强的细胞毒性和调节功能。基因表达分析显示，与CD28+细胞相比，CD28− T细胞发生了深刻的变化，并支持它们的功能差异。在这里，我们回顾了我们对CD28− T细胞及其在年龄相关的免疫功能下降中的作用的最新进展。
The accumulation of CD28− T cells, particularly within the CD8 subset, is one of the most prominent changes during T cell homeostasis and function associated with aging in human. CD28, a major co-stimulatory receptor, is responsible for the optimal antigen-mediated T cell activation, proliferation, and survival of T cells. CD28− T cells exhibit reduced antigen receptor diversity, defective antigen-induced proliferation, and a shorter replicative lifespan while showing enhanced cytotoxicity and regulatory functions. Gene expression analyses reveal profound changes of CD28− T cells in comparison to their CD28+ counterparts and support their functional differences. Here we review the recent advance of our understanding of CD28− T cells and their role in age-associated decline of immune function.
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影响因子：
2.7
作者：
CLEMENT, MV;HADDAD, P;SASPORTES, M
通讯作者：
SASPORTES, M
DOI：
10.1084/jem.20021127
发表时间：
2003-01-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chan HW;Kurago ZB;Stewart CA;Wilson MJ;Martin MP;Mace BE;Carrington M;Trowsdale J;Lutz CT
通讯作者：
Lutz CT
影响因子：
3.8
作者：
Effros, RB;Allsopp, R;Giorgi, JV
通讯作者：
Giorgi, JV
影响因子：
11.4
作者：
Alessi, DR;Andjelkovic, M;Hemmings, BA
通讯作者：
Hemmings, BA
影响因子：
--
作者：
Goronzy, JJ;Matteson, EL;Weyand, CM
通讯作者：
Weyand, CM