Fifty years later: the disk goes to the prom.
Fifty years later: the disk goes to the prom.
复制标题
DOI：
10.1172/jci36515
复制
发表时间：
2008-08
期刊：
影响因子：
--
通讯作者：
M. Kleinman;J. Ambati
中科院分区：
文献类型：
--
作者：
M. Kleinman;J. Ambati
虽然年龄相关性黄斑变性是世界上最普遍的黄斑疾病，但通过对罕见遗传性黄斑病的遗传关联研究，已经发现了许多关于视觉分子基础的发现。在这一期的JCI中，Yang等人提出了一项功能遗传学研究，该研究确定了视网膜感光盘阵列生物发生中最为人所知的干细胞和/或祖细胞标记物-这项研究支持了一个既定的模型，其中磁盘形态发生通过膜外翻，并扩展了其他最近的研究分配PROM 1的重要功能以外的干细胞龛。
Although age-related macular degeneration is the most prevalent macular disease in the world, numerous discoveries regarding the molecular bases of vision have been made through genetic association studies of rare inherited maculopathies. In this issue of the JCI, Yang et al. present a functional genetics study that identifies a role for prominin 1 (PROM1), best known as a stem cell and/or progenitor cell marker, in the biogenesis of retinal photoreceptor disk arrays (see the related article beginning on page 2908). This study supports an established model in which disk morphogenesis occurs through membrane evagination and extends other recent studies assigning PROM1 important functions outside of the stem cell niche.