NATURAL-HISTORY OF CHRONIC AIR-FLOW OBSTRUCTION
NATURAL-HISTORY OF CHRONIC AIR-FLOW OBSTRUCTION
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DOI：
10.1136/bmj.1.6077.1645
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发表时间：
1977-01-01
影响因子：
105.7
通讯作者：
PETO, R
中科院分区：
文献类型：
--
作者：
FLETCHER, C;PETO, R
对伦敦工作男性进行了一项慢性阻塞性肺疾病早期发展的前瞻性流行病学研究。研究结果表明，一秒钟用力呼气量（FEV1）福尔斯在一生中逐渐下降，但在大多数非吸烟者和许多吸烟者中，临床上显著的气流阻塞从未发生。然而，在易感人群中，吸烟会导致不可逆的阻塞性变化。如果易感吸烟者停止吸烟，他的肺功能不会恢复，但FEV1的平均进一步损失率将恢复正常。因此，在中年早期对吸烟者进行肺功能筛查，如果能诱导功能下降者戒烟，则可以预防严重或致命的阻塞性肺病。感染过程和慢性粘液分泌过多不会导致慢性气流阻塞进展更快。因此，有两个很大程度上不相关的疾病过程，慢性气流阻塞和高分泌障碍（包括感染过程）。
A prospective epidemiological study of the early stages of the development of chronic obstructive pulmonary disease was performed on London working men. The findings showed that forced expiratory volume in one second (FEV1) falls gradually over a lifetime, but in most non-smokers and many smokers clinically significant airflow obstruction never develops. In susceptible people, however, smoking causes irreversible obstructive changes. If a susceptible smoker stops smoking he will not recover his lung function, but the average further rates of loss of FEV1 will revert to normal. Therefore, severe or fatal obstructive lung disease could be prevented by screening smokers' lung function in early middle age if those with reduced function could be induced to stop smoking. Infective processes and chronic mucus hypersecretion do not cause chronic airflow obstruction to progress more rapidly. There are thus two largely unrelated disease processes, chronic airflow obstruction and the hypersecretory disorder (including infective processes).