Anti-inflammatory effect of ethanolic extract of spine, skin and rind of Jack fruit peel - A comparative study
Anti-inflammatory effect of ethanolic extract of spine, skin and rind of Jack fruit peel - A comparative study
复制标题
DOI：
10.1080/14786419.2017.1378200
复制
发表时间：
2018-01-01
影响因子：
2.2
通讯作者：
Prabhu, R. Lakshmipathy
中科院分区：
文献类型：
--
作者：
Meera, M.;Ruckmani, A.;Prabhu, R. Lakshmipathy
本研究对菠萝蜜果皮、果皮和果皮的乙醇粗提物进行了化学成分鉴定和抗炎活性评价。用福林的Ciocalteu试剂和三氯化铝方法测定多酚和类黄酮类化合物的含量，结果表明，多酚类化合物的单宁酸当量为316、355和382 mg单宁酸当量/g，皮中黄酮的含量分别为96.7、131.6和164.6 mg当量/g。在体外和体内实验中，三种提取物的抗炎活性均与双氯芬酸相当。皮肤显示出最大的抗炎活性，皮肤对环氧合酶-2和脊椎有优先抑制作用，皮肤在体外对环氧合酶-1和环氧合酶-2都有抑制作用。
The present study was conducted to identify the chemical constituents and evaluate the anti-inflammatory activity of crude ethanolic extracts of spine, skin and rind of jack fruit (Artocarpus heterophyllus) peel. Polyphenol and flavonoid contents were assessed using Folin's Ciocalteu reagent and aluminium chloride methods which revealed 316, 355 and 382 mg tannic acid equivalent/g of polyphenol and 96.7, 131.6 and 164.6 mg quercetin equivalent/g of flavonoid in spine, skin and rind, respectively. Anti-inflammatory activity of all three extracts was comparable to diclofenac in vitro and in vivo studies. Skin exhibited maximum anti-inflammatory activity, rind had preferential inhibition on Cyclooxygenase-2 and spine and skin inhibited both Cyclooxygenase-1 and 2 in vitro.[GRAPHICS]