Stroke induces specific alteration of T memory compartment controlling auto-reactive CNS antigen-specific T cell responses
Stroke induces specific alteration of T memory compartment controlling auto-reactive CNS antigen-specific T cell responses
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DOI：
10.1016/j.jns.2016.06.039
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发表时间：
2016-09-15
影响因子：
4.4
通讯作者：
Meisel, Andreas
中科院分区：
文献类型：
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作者：
Klehmet, Juliane;Hoffmann, Sarah;Meisel, Andreas
中风后自身反应性是否以及何时发生仍然是一个有争议的问题。通过使用由髓鞘碱性蛋白（MBP）和髓鞘少突胶质细胞糖蛋白（MOG）组成的重叠15聚体肽库，我们发现急性缺血性中风中免疫显性的MOG和MBP T细胞反应频率增加，这与初始T细胞以及CD8 + 终末分化效应记忆T细胞（TEMRA）频率降低有关。自身反应性中枢神经系统抗原特异性T细胞反应以及T细胞亚群的改变在中风后的长期随访中恢复正常。我们的研究结果表明，中风诱导的免疫抑制可能作为一种适应性机制，以抑制有害且持久的中枢神经系统抗原特异性免疫反应。（C）2016由爱思唯尔出版集团出版
Whether and when auto-reactivity after stroke occurs is still a matter of debate. By using overlapping 15mer peptide pools consisting of myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) we show increased frequencies of immunodominant MOG- and MBP T cell responses in acute ischemic stroke which were associated with reduced frequencies of naive T cells as well as CD8 + TEMRA cells. Auto-reactive CNS antigen -specific T cells responses as well as alterations of T cell subpopulations normalized in long-term follow up after stroke. Our findings suggest that stroke-induced immunodepression might function as an adaptive mechanism in order to inhibit harmful and long-lasting CNS antigen-specific immune responses. (C) 2016 Published by Elsevier B.V.