Physical activity and metabolic risk in individuals with a family history of type 2 diabetes
Physical activity and metabolic risk in individuals with a family history of type 2 diabetes
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DOI：
10.2337/dc06-1883
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发表时间：
2007-02-01
期刊：
影响因子：
16.2
通讯作者：
Wareham, Nicholas J.
中科院分区：
文献类型：
--
作者：
Ekelund, Ulf;Griffin, Simon J.;Wareham, Nicholas J.
目的 - 我们试图检查 2 型糖尿病风险增加的超重个体中不同维度的体力活动与中间和聚集代谢危险因素之间的独立关联，为未来的预防行动提供信息。 研究设计和方法 - 我们通过加速度测量法对 258 名有 2 型糖尿病家族史的成年人（年龄 30-50 岁）进行全身运动和体力活动的其他五个子组成部分的测量。我们通过增量跑步机运动测试来估计有氧健身。我们通过标准方法通过生物阻抗和腰围、血压、空腹甘油三酯、HDL 胆固醇、葡萄糖和胰岛素测量身体成分。我们为聚类风险构建了一个标准化的连续分布变量。 结果 - 全身运动（计算中心点日（-1））与六个风险因素中的三个（空腹甘油三酯、胰岛素和高密度脂蛋白）显着且独立相关，并且在调整年龄、性别和肥胖后，与聚类代谢风险（P = 0.004）相关。中等强度和高强度体力活动 (MPVA) 所花费的时间与聚集代谢风险独立相关 (P = 0.03)。调整混杂因素后，5 分钟和 10 分钟 MVPA、久坐时间、低强度活动时间和有氧健身与集群风险没有显着相关。结论 - 全身运动与心血管疾病和代谢疾病的中间表型风险因素相关，并且与独立于有氧健身和肥胖的集群代谢风险相关。增加久坐和超重个体的体力活动总量可能对代谢危险因素产生有益影响。
OBJECTIVE - We sought to examine the independent associations between different dimensions of physical activity with intermediary and clustered metabolic risk factors in overweight individuals with an increased risk of type 2 diabetes to inform future preventive action.RESEARCH DESIGN AND METHODS - We measured total body movement and five other subcomponents of physical activity by accelerometry in 258 adults (aged 30-50 years) with a family history of type 2 diabetes. We estimated aerobic fitness from an incremental treadmill exercise test. We measured body composition by bioimpedance and waist circumference, blood pressure, fasting triglycerides, HDL cholesterol, glucose, and insulin with standard methods. We constructed a standardized continuously distributed variable for clustered risk.RESULTS - Total body movement (counts center dot day(-1)) was significantly and independently associated with three of six risk factors (fasting triglycerides, insulin, and HDL) and with clustered metabolic risk (P = 0.004) after adjustment for age, sex, and obesity. Time spent at moderate- and vigorous-intensity physical activity (MPVA) was independently associated with clustered metabolic risk (P = 0.03). Five- and 10-min bouts of MVPA, time spent sedentary, time spent at light-intensity activity, and aerobic fitness were not significantly related with clustered risk after adjustment for confounding factors.CONCLUSIONS - Total body movement is associated with intermediary phenotypic risk factors for cardiovascular disease and metabolic disease and with clustered metabolic risk independent of aerobic fitness and obesity. Increasing the total amount of physical activity in sedentary and overweight individuals may have beneficial effects on Metabolic risk factors.