THE USE OF CREVICULAR FLUID PROSTAGLANDIN-E2 LEVELS AS A PREDICTOR OF PERIODONTAL ATTACHMENT LOSS
THE USE OF CREVICULAR FLUID PROSTAGLANDIN-E2 LEVELS AS A PREDICTOR OF PERIODONTAL ATTACHMENT LOSS
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DOI：
10.1111/j.1600-0765.1986.tb01443.x
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发表时间：
1986-03-01
影响因子：
3.5
通讯作者：
VANDYKE, TE
中科院分区：
文献类型：
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作者：
OFFENBACHER, S;ODLE, BM;VANDYKE, TE
收集了41名成人牙周炎患者(AAP III和IV型)至少18个月和最长3年的纵向数据。每3个月测量一次Ramfjord附着平面并采集每颗牙的窝沟液(Cf)。每名患者在每次就诊时测定平均全口前列腺素E_2(MCF-PGE)值。持续三个月的监测，直到一个单一的部位显示出统计学上和临床上显著的依恋丧失(ALOSS)事件。结果表明，在ALOSS患者中，与以前相比，ALOSS患者的MCF-PGE显着升高。此外，与对侧无ALOSS对照部位相比，有ALOSS的部位水平升高(305.6.+-)。56.5比65.7。+-。6.89纳克毫升(平均+-扫描电子显微镜))。治疗后1个月，Cf-PGE水平降至16.9±-。ALOSS部位3.4ngml。由于MCF-PGE水平在附着丧失之前升高，在实际接受ALOSS的部位达到最大值，并在治疗后下降，因此研究了使用MCF-PGE水平预测未来ALOSS发作的可能性。ALOSS患者的MCFPGE水平为113.4.+-。ALOSS患者发病前6个月MCF-PGE水平为9.0 ng/ml，显著高于非ALOSS患者的50.1.+-。7.1.以MCF-PGE水平作为筛查试验的分析表明，该方法具有高度的敏感性、特异性和预测值0.92、0.95。因此，该方法作为确定患者是否处于缓解状态或即将经历依恋丧失发作的诊断工具具有显著的优点。
Longitudinal data were collected over a period of at least 18 months and up to 3 years on 41 adult periodontitis patients (AAP Type III and IV). Ramfjord attachment level measurements and sampling of crevicular fluid (CF) at each tooth were repeated every 3 months. A mean full mouth CF prostaglandin E2 (MCF-PGE) value was determined for each patient at each visit. The three-month monitoring was continued until a single site demonstrated a statistically and clinically significant attachment loss (ALOSS) episode. Results indicated that in ALOSS patients the MCF-PGE was significantly elevated at the ALOSS visit as compared to previous levels. Furthermore, the sites which had the ALOSS had elevated levels as compared to the contralateral no ALOSS control sites (305.6 .+-. 56.5 vs. 65.7 .+-. 6.89 ng ml (mean .+-. SEM)). One month following treatment the CF-PGE level dropped to 16.9 .+-. 3.4 ng ml at the ALOSS sites. Since the MCF-PGE level increases preceding the attachment loss episode, reaches a maximum at the sites which actually undergo ALOSS, and subsides following treatment, the possibility of using the MCF-PGE level to predict an oncoming future ALOSS episode was examined. The ALOSS patients had a MCF-PGE level of 113.4 .+-. 9.0 ng/ml 6 months prior to the ALOSS episode, which was significantly higher than the no ALOSS patients'' MCF-PGE level of 50.1 .+-. 7.1. Analysis of MCF-PGE levels as a screening test indicate that this measurement has a high degree of sensitivity, specificity, and a predictive value of 0.92, 0.95. Thus, this method has significant merit as a diagnostic tool to determine if a patient is in a state of remission or about to undergo an attachment loss episode.