β2-Adrenergic receptor-dependent sexual dimorphism for murine leukocyte migration
β2-Adrenergic receptor-dependent sexual dimorphism for murine leukocyte migration
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DOI：
10.1016/j.jneuroim.2007.02.010
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发表时间：
2007-05-01
影响因子：
3.3
通讯作者：
Green, Paul G.
中科院分区：
文献类型：
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作者：
de Coupade, Catherine;Brown, Adrienne S.;Green, Paul G.
在野生型FVB小鼠中，白细胞对脂多糖的募集是性二态的，雌性小鼠募集的白细胞数量更多。在雄性β(2)-肾上腺素能受体敲除小鼠(在同源FVB背景下培育)，招募的白细胞数量增加了近4倍，而在雌性小鼠中没有变化，消除了白细胞迁移中的性别二型性。虽然野生型雄性小鼠募集的CD62L(+)和CD11a(+)白细胞明显减少，但只有雄性β-肾上腺素能受体敲除小鼠募集的CD11a(+)白细胞数量增加，再次消除了性别二型性。因此，白细胞的迁移和CD11a(+)黏附分子在男性中的表达，而在女性中不是，白细胞是β-肾上腺素能受体依赖性的。我们的发现支持了β(2)-肾上腺素能受体机制在炎症反应中的作用，并提示男性白细胞上的β(2)-肾上腺素能受体在应激对炎症性疾病的影响中参与了性别二型性。(C)2007 Elsevier B.V.保留所有权利。
In wild-type FVB mice, leukocyte recruitment to lipopolysaccharide was sexually dimorphic, with a greater number of leukocytes recruited in females. In male beta(2)-adrenergic receptor knock out mice (bred on a congenic FVB background) the number of leukocytes recruited was increased similar to 4-fold, while in females there was no change, eliminating sexual dimorphism in leukocyte migration. While there were significantly fewer recruited CD62L(+) and CD11a(+) leukocytes in wild-type males, only in male p-adrenergic receptor knock out mice was there an increase in the number of recruited CD11a(+) leukocytes, again eliminating sexual dimorphism. Thus, leukocyte migration and CD11a(+) adhesion molecule expression in male, but not in female, leukocytes is beta-adrenergic receptor-dependent. Our findings provide support for a role Of beta(2)-adrenergic receptor mechanisms in the inflammatory response, and suggest that beta(2)-adrenergic receptor on male leukocytes contributes to sexual dimorphism in the effect of stress on inflammatory diseases. (c) 2007 Elsevier B.V. All rights reserved.