Peptide protected gold clusters: chemical synthesis and biomedical applications
Peptide protected gold clusters: chemical synthesis and biomedical applications
复制标题
肽保护的金簇：化学合成和生物医学应用
作者：
Yuan Qing;Wang Yaling;Zhao Lina;Liu Ru;Gao Fuping;Gao Liang;Gao Xueyun;Yuan Qing;Wang Yaling;Zhao Lina;Liu Ru;Gao Fuping;Gao Liang;Gao Xueyun;Gao L;Gao L
具有原子精度的贵金属团簇作为原子与纳米粒子之间的差距，在催化、能量转换、生物传感和生物医学等领域具有重要的应用价值，一直受到人们的广泛关注。与普通化学合成有很大不同，肽缀合金属簇的一步仿生合成已被开发出来，以满足新兴生物应用的需求。在温和的条件下，合理设计并精心合成了含有金属捕获基团、反应基团和靶向基团的多功能肽，以制备原子级精确的肽保护金属簇。其中，肽保护的Au Cs（peptide-Au Cs）具有纳米尺寸、高光稳定性、良好的生物相容性、精确的化学式和特异的蛋白靶向能力等诸多独特的优点。本文通过介绍肽-金-铯在生物成像、生物分析和治疗应用方面的新进展，重点介绍其在潜在的治疗诊断领域的最新进展。Au Cs与生物系统的相互作用及其可能机制也是我们关注的主题。我们预计，对基于Au Cs的治疗诊断应用的快速增长的兴趣将吸引各个学科的更广泛关注。
Bridging the gap between atoms and nanoparticles, noble metal clusters with atomic precision continue to attract considerable attention due to their important applications in catalysis, energy transformation, biosensing and biomedicine. Greatly different to common chemical synthesis, a one-step biomimetic synthesis of peptide-conjugated metal clusters has been developed to meet the demand of emerging bioapplications. Under mild conditions, multifunctional peptides containing metal capturing, reactive and targeting groups are rationally designed and elaborately synthesized to fabricate atomically precise peptide protected metal clusters. Among them, peptide-protected Au Cs (peptide–Au Cs) possess a great deal of exceptional advantages such as nanometer dimensions, high photostability, good biocompatibility, accurate chemical formula and specific protein targeting capacity. In this review article, we focus on the recent advances in potential theranostic fields by introducing the rising progress of peptide–Au Cs for biological imaging, biological analysis and therapeutic applications. The interactions between Au Cs and biological systems as well as potential mechanisms are also our concerned theme. We expect that the rapidly growing interest in Au Cs-based theranostic applications will attract broader concerns across various disciplines.