Syn Selective Vinylogous Mukaiyama Aldol Reaction Using Z,E-Vinylketene N,O-Acetal with Acetals.
Syn Selective Vinylogous Mukaiyama Aldol Reaction Using Z,E-Vinylketene N,O-Acetal with Acetals.
复制标题
使用 Z,E-乙烯基乙烯酮 N,O-缩醛与缩醛进行顺式选择性乙烯基向山醇醛反应。
作者：
Naoya Sagawa;Hiroki Moriya;Seijiro Hosokawa
以（E）-3-戊烯酸和l-缬氨酸为原料，合成了具有手性助剂的Z，E-乙烯基烯酮甲硅烷基N，O-缩醛，实现了乙烯基-Mukaiyama羟醛缩合反应的立体选择性。反应顺利进行，得到高立体选择性的顺式加成物。由于产物具有δ-烷氧基-γ-甲基-α，β-不饱和酰亚胺结构，该反应适合于短流程合成聚酮化合物。
Stereoselective vinylogous Mukaiyama aldol reactions using the Z,E-vinylketene silyl N,O-acetal possessing a chiral auxiliary, derived from (E)-3-pentenoic acid and l-valine, have been achieved. The reaction proceeded smoothly to give a syn adduct in high stereoselectivity. Since the products possess structures including δ-alkoxy-γ-methyl-α,β-unsaturated imide, this reaction would be applicable to synthesize polyketides in a short procedure.
影响因子：
15
作者：
Evans, DA;Connell, BT
通讯作者：
Connell, BT
影响因子：
16.6
作者：
Byrne, Liam;Sola, Jordi;Clayden, Jonathan
通讯作者：
Clayden, Jonathan