Does central sensitization help explain idiopathic overactive bladder?
Does central sensitization help explain idiopathic overactive bladder?
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DOI：
10.1038/nrurol.2016.95
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发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
Bruehl S
中科院分区：
文献类型：
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作者：
Reynolds WS;Dmochowski R;Wein A;Bruehl S
膀胱过度活动综合征（OAB）的病理生理机制包括外周和中枢神经系统感觉通路功能障碍，导致膀胱超敏反应。中枢致敏描述了一种脊髓超敏反应的诱导状态，其与多种慢性疼痛疾病相关，这些疾病与OAB具有许多共同属性，尽管不存在疼痛。因此，中枢致敏的概念可能与理解OAB综合征的机制和临床表现有关。了解中枢致敏的病理生理学和临床表现，以及支持中枢致敏在OAB中的作用的证据，包括中枢致敏机制对OAB患者治疗的潜在影响，可以为这种疾病患者的治疗提供一种新的方法。这种方法将特别适用于患有中枢致敏相关合并症的患者，并有可能改善这些患者的结局。
The pathophysiological mechanisms underlying overactive bladder syndrome (OAB) can include dysfunction of sensory pathways of the peripheral and central nervous systems, resulting in bladder hypersensitivity. Central sensitization describes an induced state of spinal hypersensitivity that is associated with a variety of chronic pain disorders that share many attributes with OAB, albeit without the presence of pain. As such, the concept of central sensitization might be relevant to understanding the mechanisms and clinical manifestations of OAB syndrome. An understanding of the pathophysiology and clinical manifestations of central sensitization, and the evidence that supports a role of central sensitization in OAB, including the potential implications of mechanisms of central sensitization for the treatment of patients with OAB could provide a novel approach to the treatment of patients with this disease. Such an approach would be especially relevant to those patients with central sensitization-related comorbidities, and has the potential to improve the outcomes of these patients in particular.