Sensitivity analysis and diagnostic accuracy of the Brief Smell Identification Test in patients with chronic rhinosinusitis
Sensitivity analysis and diagnostic accuracy of the Brief Smell Identification Test in patients with chronic rhinosinusitis
复制标题
DOI：
10.1002/alr.21670
复制
发表时间：
2016-03-01
影响因子：
6.4
通讯作者：
Smith, Timothy L.
中科院分区：
文献类型：
--
作者：
El Rassi, Edward;Mace, Jess C.;Smith, Timothy L.
背景简单气味识别测试(BSIT)是气味识别测试(SIT)的缩写版本，用于评估嗅觉功能。尽管BSIT可以在不到5分钟的时间内有效地实施，但BSIT与慢性鼻-鼻窦炎(CRS)患者SIT的准确性尚不清楚。共有183名参与者在初始登记期间提供了BSIT和SIT嗅觉功能评分。用皮尔逊相关系数(r(P))评估BSIT和SIT评分之间的线性关系。以SIT评分为金标准，确定BSIT评分的敏感性、特异性和准确性。结果所有受试者的BSIT评分与SIT评分之间存在很强的双变量线性关联(r(P)=0.893；p<；0.001)。与SIT相比，BSIT被确认为嗅觉异常的患者比例明显较低(分别为47%和68%；p<；0.001)。以目前定义的8分作为嗅觉功能异常的分界点，BSIT的灵敏度为63%，特异度为88%，总体准确率为71%。在CRS患者中，BSIT评分与SIT评分密切相关，但BSIT低估了建议的8分的嗅觉功能障碍。将BSIT评分增加到9分可提高BSIT的敏感性和准确性。
BackgroundThe Brief Smell Identification Test (BSIT) is an abbreviated version of the Smell Identification Test (SIT) used to assess olfactory function. Although the BSIT can be efficiently administered in under 5 minutes, the accuracy of the BSIT in relation to the SIT in patients with chronic rhinosinusitis (CRS) is unknown.MethodsPatients with CRS were recruited as part of an ongoing multi-institutional observational cohort study. A total of 183 participants provided both BSIT and SIT olfactory function scores during initial enrollment. Linear associations between BSIT and SIT scores were evaluated using Pearson's correlation coefficients (r(p)). The sensitivity, specificity, and accuracy of BSIT scores were determined using SIT scores as the gold standard.ResultsA strong bivariate linear association was found between BSIT and SIT scores (r(p) = 0.893; p < 0.001) for all participants. A significantly lower proportion of patients were identified as having abnormal olfaction using the BSIT compared to the SIT (47% vs 68%, respectively; p < 0.001). Using the currently defined score of 8 as a cut-point for abnormal olfactory function, the BSIT demonstrated a sensitivity of 63% and specificity of 88% with an overall accuracy of 71%. Increasing the cut-point to 9 resulted in an increased sensitivity of 86%, a specificity of 76%, and an improved overall accuracy of 83%.ConclusionIn patients with CRS, BSIT scores strongly correlate with SIT scores; however, the BSIT underestimates olfactory dysfunction as defined by the suggested cut-point of 8. Increasing the cut-point to 9 increased the sensitivity and accuracy of the BSIT.