Multifunctional Fiber‐Based Optoacoustic Emitter as a Bidirectional Brain Interface
Multifunctional Fiber‐Based Optoacoustic Emitter as a Bidirectional Brain Interface
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基于多功能光纤的光声发射器作为双向大脑接口
DOI：
10.1002/adhm.202300430
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发表时间：
2023
影响因子：
10
通讯作者：
Yang, Chen
中科院分区：
文献类型：
--
作者：
Zheng, Nan;Jiang, Ying;Jiang, Shan;Kim, Jongwoon;Chen, Guo;Li, Yueming;Cheng, Ji‐Xin;Jia, Xiaoting;Yang, Chen
同时具有“写”和“读”功能的双向大脑接口可以成为基础研究和潜在的神经疾病临床治疗的重要工具。本文报道了一种小型化的多功能光纤光声发射器(MFOE)，它集成了用于写入的同时光声刺激和用于读取的神经回路的电生理记录。由于神经元对声波的固有反应能力，不需要病毒转染法。光声波与电场的正交性为避免电刺激和记录之间的干扰提供了一种解决方案。MFOE的刺激功能首先在培养的大脑皮层神经元中使用钙成像进行验证。在体内应用mFOE成功地同时进行光声刺激和脑活动的电记录，在小鼠的海马区被证实在急性和慢性应用长达1个月。在这些应用之后，轻微的脑组织损伤被证实。利用mFOE同时实现神经刺激和记录的能力，为研究神经回路开辟了新的可能性，并为超声波神经刺激的研究带来了新的见解。
A bidirectional brain interface with both “write” and “read” functions can be an important tool for fundamental studies and potential clinical treatments for neurological diseases. Herein, a miniaturized multifunctional fiber‐based optoacoustic emitter (mFOE) is reported thatintegrates simultaneous optoacoustic stimulation for “write” and electrophysiology recording of neural circuits for “read”. Because of the intrinsic ability of neurons to respond to acoustic wave, there is no requirement of the viral transfection. The orthogonality between optoacoustic waves and electrical field provides a solution to avoid the interference between electrical stimulation and recording. The stimulation function of the mFOE is first validated in cultured ratcortical neurons using calcium imaging. In vivo application of mFOE for successful simultaneous optoacoustic stimulation and electrical recording of brain activities is confirmed in mouse hippocampus in both acute and chronical applications up to 1 month. Minor brain tissue damage is confirmed after these applications. The capability of simultaneous neural stimulation and recording enabled by mFOE opens up new possibilities for the investigation of neural circuits and brings new insights into the study of ultrasound neurostimulation.