Cyclic nucleotides, gut physiology and inflammation.
Cyclic nucleotides, gut physiology and inflammation.
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DOI：
10.1111/febs.15198
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发表时间：
2020-05
期刊：
影响因子：
--
通讯作者：
Visweswariah SS
中科院分区：
文献类型：
--
作者：
Prasad H;Shenoy AR;Visweswariah SS
肠道功能和体内平衡的失调会影响整个有机体的整体健康。腹泻病是 5 岁以下儿童死亡的第二大原因，全球每年报告 17 亿儿童腹泻病例。伴随腹泻发作的是肠道生理和结构的许多继发影响，例如肠道粘膜屏障的侵蚀，促进肠道对正常微生物组的进一步炎症。在这里，我们重点关注致病菌介导的腹泻，强调环腺苷 3',5'-单磷酸和环鸟苷 3',5'-单磷酸在驱动信号输出中的作用，从而导致肠道上皮细胞分泌水和离子。我们还推测这种离子的异常流出和流入如何调节炎症体信号传导，从而调节细胞存活以及肠道结构和功能的维持。
Misregulation of gut function and homeostasis impinges on the overall wellbeing of the entire organism. Diarrheal disease is the second leading cause of death in children under 5 years of age, and globally, 1.7 billion cases of childhood diarrhea are reported every year. Accompanying diarrheal episodes are a number of secondary effects in gut physiology and structure, such as erosion of the mucosal barrier that lines the gut, facilitating further inflammation of the gut in response to the normal microbiome. Here, we focus on pathogenic bacteria-mediated diarrhea, emphasizing the role of cyclic adenosine 3′,5′-monophosphate and cyclic guanosine 3′,5′-monophosphate in driving signaling outputs that result in the secretion of water and ions from the epithelial cells of the gut. We also speculate on how this aberrant efflux and influx of ions could modulate inflammasome signaling, and therefore cell survival and maintenance of gut architecture and function.
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影响因子：
15.3
作者：
Braun, M C;He, J;Wu, C Y;Kelsall, B L
通讯作者：
Kelsall, B L
DOI：
10.1152/ajpgi.00484.2001
发表时间：
2002-07-01
影响因子：
4.5
作者：
Crane, JK;Olson, RA;Duffey, ME
通讯作者：
Duffey, ME
影响因子：
158.5
作者：
Fiskerstrand, Torunn;Arshad, Najla;Knappskog, Per M.
通讯作者：
Knappskog, Per M.
影响因子：
2.8
作者：
DUEBBERT, IE;PETERSON, JW
通讯作者：
PETERSON, JW
影响因子：
6.4
作者：
GILL, DM;EVANS, DJ;EVANS, DG
通讯作者：
EVANS, DG