Detecting fatty acids of dietary origin in normal and cancerous human breast tissue by 13C nuclear magnetic resonance spectroscopy.
Detecting fatty acids of dietary origin in normal and cancerous human breast tissue by 13C nuclear magnetic resonance spectroscopy.
复制标题
通过 13C 核磁共振波谱检测正常和癌性人类乳腺组织中膳食来源的脂肪酸。
DOI：
10.1038/bjc.1993.337
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发表时间：
1993
影响因子：
8.8
通讯作者：
Knop,RH
中科院分区：
文献类型：
--
作者：
Victor,TA;Bergman,A;Knop,RH
天然丰度13C NMR用于确定来自健康和癌症患者中的人乳腺的纤维脂肪组织和乳腺癌组织中存在的脂肪酸亚类的相对量。当脂肪组织占癌组织的10%以上时，获得了与三酰甘油酯的碳原子相对应的共振。当脂肪组织的百分比较低时，也观察到对应于磷脂和蛋白质的共振。癌症和非癌症患者脂肪组织中的不饱和脂肪酸水平没有显著差异，但是，与非癌症组织相比，癌症组织中的单不饱和脂肪酸和饱和脂肪酸水平存在显著差异，这两种组织类型中的多不饱和脂肪酸水平也存在几乎显著的差异。这些结果表明，在肿瘤乳腺组织细胞脂质成分的改变。
Natural abundance 13C NMR was used to determine relative amounts of fatty acid subclasses present in fibroadipose tissue from the human breast in healthy and cancer patients and in breast carcinoma tissue. Resonances corresponding to the carbon atoms of triacylglycerides were obtained when adipose tissue constituted more than 10% of the carcinoma. Resonances corresponding to phospholipids and proteins were also observed when the percentage of adipose tissue was lower. No significant difference between the levels of unsaturated fatty acids in adipose tissue from cancer and non-cancer patients was found. However, significant differences in the levels of monounsaturated and saturated fatty acids of carcinoma compared to non-cancerous tissue was found, as was a nearly significant difference for the levels of polyunsaturated fatty acids in these two tissue types. These findings suggest an alteration of cellular lipid composition in neoplastic mammary tissue.