Antimicrobial properties of ternary eutectic aluminum alloys
Antimicrobial properties of ternary eutectic aluminum alloys
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DOI：
10.1007/s10534-018-0119-1
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发表时间：
2018-06
期刊：
影响因子：
3.5
通讯作者：
C. Hahn;M. Hans;C. Hein;A. Dennstedt;F. Mücklich;P. Rettberg;C. Hellweg;L. Leichert;C. Rensing;R. Moeller
中科院分区：
文献类型：
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作者：
C. Hahn;M. Hans;C. Hein;A. Dennstedt;F. Mücklich;P. Rettberg;C. Hellweg;L. Leichert;C. Rensing;R. Moeller
为了更好地了解哪些基因可能在铜或银的稳态中起关键作用，我们选择了庆应义塾收集的几个埃希氏菌碰撞突变体进行分析。每一个选择。共变体缺失了一个预测编码同源重组蛋白的基因，或含有与铜或银转运或转化直接相关的功能。研究了这些菌株在纯铜表面、不锈钢表面以及铝、铜和/或银合金表面的存活情况。当暴露在纯铜表面时，E。coliΔcueOwas最敏感的，而不是。coliΔcopAwas在测试的不同菌株中最具抗性。然而，我们观察到在敏感性方面有不同的趋势。暴露于Al-Ag-Cu系合金时的共应变。而暴露于e。杆菌ΔcopAandE。coliΔrecAto Al-Ag合金，暴露于Al-Cu合金后未检测到任何影响。测定铜离子释放量和细胞相关铜离子浓度。coliΔcopAand野生型。大肠杆菌暴露在纯铜表面后。总之，与二元合金相比，三元共晶合金（Al-Ag-Cu）具有最高的抗菌效果，因此值得进一步研究。
SeveralEscherichia colideletion mutants of the Keio collection were selected for analysis to better understand which genes may play a key role in copper or silver homeostasis. Each of the selectedE. colimutants had a deletion of a single gene predicted to encode proteins for homologous recombination or contained functions directly linked to copper or silver transport or transformation. The survival of these strains on pure copper surfaces, stainless steel, and alloys of aluminum, copper and/or silver was investigated. When exposed to pure copper surfaces,E. coliΔcueOwas the most sensitive, whereasE. coliΔcopAwas the most resistant amongst the different strains tested. However, we observed a different trend in sensitivities inE. colistrains upon exposure to alloys of the system Al–Ag–Cu. While minor antimicrobial effects were detected after exposure ofE. coliΔcopAandE. coliΔrecAto Al–Ag alloys, no effect was detected after exposure to Al–Cu alloys. The release of copper ions and cell-associated copper ion concentrations were determined forE. coliΔcopAand the wild-typeE. coliafter exposure to pure copper surfaces. Altogether, compared to binary alloys, ternary eutectic alloys (Al–Ag–Cu) had the highest antimicrobial effect and thus, warrant further investigation.