Update in andrology
Update in andrology
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DOI：
10.1210/jc.2007-1431
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发表时间：
2007-12-01
影响因子：
5.8
通讯作者：
Handelsman, David J.
中科院分区：
文献类型：
--
作者：
Handelsman, David J.
背景：这是一份基于内分泌学会 2007 年度科学会议上的演讲的受邀评审。目的：评审的目的是突出显示过去 1-2 年内发表的男科领域最重要的同行评审论文。证据获取：这是对过去 2 年内在主要内分泌学期刊上发表的所有论文的全面调查，并通过个人知识和文献检索以及对更多内容的电子邮件调查进行了增强证据综合：从建议论文列表中，对被认为最重要的简短列表的发现进行了审查，旨在重点关注影响男科领域思考和实践的发现。结论：强调的重要进展包括通过睾丸精子抽吸结合胞浆内精子注射体外受精，为患有克兰费尔特综合征的男性建立遗传亲子关系，作为一种现实的治疗选择，使用人口登记关联数据来定义克兰费尔特综合征的自然史社区中的综合症，并确定 SHBG 结合睾酮的活跃细胞摄取机制，挑战游离激素假说的准公理状态。最近回顾的其他重要贡献包括睾酮对前列腺的影响、男性激素避孕、美国男性血液睾酮浓度可能的时间趋势，以及内分泌学会关于睾酮测定的立场文件和睾酮处方指南。
Context: This is an invited review based on a presentation at the 2007 Annual Scientific Meeting of The Endocrine Society.Objective: The objective of the review was to highlight a selection of the most important peer-reviewed papers in andrology published over the last 1-2 yr.Evidence Acquisition: This was a comprehensive survey of all papers published in major endocrinology journals over the last 2 yr augmented by personal knowledge and literature searching as well as an e-mail survey of more than 40 leading andrologists.Evidence Synthesis: From the list of suggested papers, the findings of a short list considered the most important were reviewed, aiming to focus on findings that influence thinking and practice in the field of andrology.Conclusions: Important advances highlighted included establishing genetic paternity for men with Klinefelter's syndrome as a realistic therapeutic option via testicular sperm aspiration coupled with intracytoplasmic sperm injection in vitro fertilization, using population registry linkage data to define the natural history of Klinefelter's syndrome in the community and identifying active cellular uptake mechanisms for SHBG-bound testosterone challenging the quasi-axiomatic status of the free hormone hypothesis. Other important recent contributions reviewed are on testosterone effects on the prostate, hormonal male contraception, possible temporal trends in blood testosterone concentrations in American men, and The Endocrine Society's position papers on testosterone assays and guidelines on testosterone prescribing.