Log-normal distribution of equiefective doses of norepinephrine and acetylcholine in several tissues.
Log-normal distribution of equiefective doses of norepinephrine and acetylcholine in several tissues.
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去甲肾上腺素和乙酰胆碱在几种组织中的等效剂量的对数正态分布。
DOI：
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发表时间：
1972
影响因子：
3.5
通讯作者：
L. Jellett
中科院分区：
文献类型：
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作者：
W. Fleming;D. Westfall;I. S. de la Lande;L. Jellett
本文报道了去甲肾上腺素在大鼠输精管、兔耳灌注动脉、兔主动脉条、猫网膜和豚鼠心房内的等效剂量频率分布和乙酰胆碱在大鼠输精管内的等效剂量频率分布。在所有六个中，算术尺度上的分布倾向于偏离正态分布，但对数尺度上的分布则没有。在具有较大N的三组数据中，通过Kolmogorov-Smirnov检验，算术频率分布与正态分布的偏离具有显著性。可以得出结论，等效剂量的激动剂的分布一般是正常的对数规模，但不是算术规模。因此，等效剂量的平均值及其显著性的统计检验应基于平均对数或其反对数，即几何平均值，而不是算术平均值。
Frequency distributions of equieffective doses of norepinephrine in the rat vas deferens, the perfused artery of the rabbit ear, the aortic strip of the rabbit, the nietitating membrane of the spinat cat and the guinea-pig atrium and of acetylcholine in the rat vas deferens are presented. In all six, the distributions on an arthmetic scale tended to deviate from normal but the distributions on a log scale did not. In the three groups of data with the larger N 's, this deviation from normal of the arithmetic frequency distribution was significant by the Kolmogorov-Smirnov test. It is concluded that the distribution of equieffective doses of agonists is generally normal on a log scale but not on an arithmetic scale. Therefore, the means of equieffective doses and the statistical tests of their significance should be based on mean logs or their antilogs, the geometric means, not on arithmetic means.