Human neuroimaging reveals the subcomponents of grasping, reaching and pointing actions
Human neuroimaging reveals the subcomponents of grasping, reaching and pointing actions
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DOI：
10.1016/j.cortex.2017.05.018
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发表时间：
2018-01-01
期刊：
影响因子：
3.6
通讯作者：
Culham, Jody C.
中科院分区：
文献类型：
--
作者：
Cavina-Pratesi, Cristiana;Connolly, Jason D.;Culham, Jody C.
虽然视觉引导的抓取和伸手的神经基础已经在外侧和内侧额顶叶网络（分别）中得到了很好的描述，但视觉运动动作的子成分的贡献尚未得到详细的探讨。使用仔细的减法逻辑，我们研究了抓握、伸手和指向动作的哪些方面驱动了涉及手部动作的视觉运动网络中关键区域的激活。对于抓取任务，我们发现激活差异基于所需的精度（精细>粗抓：顶前内沟，aIPS），举起物体的要求（抓取+举起>抓：aIPS；背侧运动前皮层，PMd；辅助运动区，SMA），以及使用的手指数量（3 /5 / 2个手指抓取：腹侧运动前皮层，PMv；运动皮层，M1和体感皮层，S1）。对于到达/指向任务，我们发现激活差异基于任务是否需要手臂移动(（食指到达点和指关节到达触摸）与不需要到达点；顶叶前上小叶（aSPOC）以及是否需要指向物体中心（（不可及点和触手对点）vs.触手对触摸：顶叶-枕叶前上皮层，aSPOC）。对于食指指向物体中心但距离较远的点触（点触和点触），我们发现激活差异可能与任务的交际性质（颞顶连接，TPJ）和精确定位目标的需要（外侧枕颞皮质，LOTC）有关。目前的研究结果阐明了手动作的不同子成分和特定大脑区域在其计算中的作用。(C) 2017 Elsevier Ltd.版权所有。
Although the neural underpinnings of visually guided grasping and reaching have been well delineated within lateral and medial fronto-parietal networks (respectively), the contributions of subcomponents of visuomotor actions have not been explored in detail. Using careful subtraction logic, here we investigated which aspects of grasping, reaching, and pointing movements drive activation across key areas within visuomotor networks implicated in hand actions. For grasping tasks, we find activation differences based on the precision required (fine > coarse grip: anterior intraparietal sulcus, aIPS), the requirement to lift the object (grip + lift > grip: aIPS; dorsal premotor cortex, PMd; and supplementary motor area, SMA), and the number of digits employed (3-/5- vs. 2-digit grasps: ventral premotor cortex, PMv; motor cortex, M1, and somatosensory cortex, S1). For reaching/pointing tasks, we find activation differences based on whether the task required arm transport ((reach-to-point with index finger and reach-to-touch with knuckles) vs. point-without-reach; anterior superior parietal lobule, aSPL) and whether it required pointing to the object centre ((point without-reach and reach-to-point) vs. reach-to-touch: anterior superior parieto-occipital cortex, aSPOC). For point-without-reach, in which the index finger is oriented towards the object centre but from a distance (point-without-reach > (reach-to-point and reach-to touch)), we find activation differences that may be related to the communicative nature of the task (temporo-parietal junction, TPJ) and the need to precisely locate the target (lateral occipito-temporal cortex, LOTC). The present findings elucidate the different subcomponents of hand actions and the roles of specific brain regions in their computation. (C) 2017 Elsevier Ltd. All rights reserved.