Cell competition-induced apical elimination of transformed cells, EDAC, orchestrates the cellular homeostasis
Cell competition-induced apical elimination of transformed cells, EDAC, orchestrates the cellular homeostasis
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DOI：
10.1016/j.ydbio.2021.03.015
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发表时间：
2021-04-05
影响因子：
2.7
通讯作者：
Fujita, Yasuyuki
中科院分区：
文献类型：
--
作者：
Kon, Shunsuke;Fujita, Yasuyuki
新出现的转化细胞常常通过与周围正常细胞的细胞竞争从上皮细胞中被清除。最近许多利用哺乳动物细胞竞争系统的研究表明，受到各种致癌因素影响的细胞会以依赖细胞死亡或不依赖细胞死亡的方式从组织中被挤出。细胞竞争介导的转化细胞清除，被称为EDAC（上皮细胞抗癌防御），代表了上皮细胞群体内一种内在的抗肿瘤活性，可降低肿瘤发生的风险。在此，我们阐述这一内稳态过程的作用和分子机制，尤其着重于哺乳动物模型。
Newly emerging transformed cells are often eliminated from the epithelium via cell competition with the surrounding normal cells. A number of recent studies using mammalian cell competition systems have demonstrated that cells with various types of oncogenic insults are extruded from the tissue in a cell death-dependent or -independent manner. Cell competition-mediated elimination of transformed cells, called EDAC (epithelial defense against cancer), represents an intrinsic anti-tumor activity within the epithelial cell society to reduce the risk of oncogenesis. Here we delineate roles and molecular mechanisms of this homeostatic process, especially focusing on mammalian models.