Duration of illness and structure of symptoms in schizophrenia.
Duration of illness and structure of symptoms in schizophrenia.
复制标题
精神分裂症的病程和症状结构。
DOI：
10.1017/s0033291799008636
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发表时间：
1999
影响因子：
6.9
通讯作者：
Mojtabai,R
中科院分区：
文献类型：
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作者：
Mojtabai,R
背景以往的研究主要集中在精神分裂症症状的横断面结构上。这项Meta分析考察了病程与症状结构的相关性。方法采用明确的标准，选择了22项关于2665例精神分裂症患者症状相关性的研究。从每个研究中，提取阴性症状(SANS)评定的阴性症状和阳性症状(SAPS)评定的阳性症状的症状对相关性。使用同质性检验来评估不同研究中症状对相关性的可变性。对于未发现同质性的症状对相关性，检验了平均病程与症状对相关性的关联。这种差异的部分原因是平均病程的变化。病程越长，负性-负性症状对相关性越低，负性-阳性症状对相关性越高。结论精神分裂症患者的症状结构随着时间的推移而演变，遵循一致的模式。在疾病的早期阶段，阴性症状和阳性症状形成了紧密联系的维度。随着时间的推移，这些维度变得不那么有凝聚力，它们之间的边界也变得不那么清晰。
BackgroundPrevious research has mainly focused on the cross-sectional structure of symptoms in schizophrenia. This meta-analysis examined the association of duration of illness with the structure of symptoms.MethodsUsing explicit criteria, 22 studies reporting on the correlations of symptoms in 2665 schizophrenic patients were selected. From each study, symptom-pair correlations for negative symptoms as rated by Scale for the Assessment of Negative Symptoms (SANS) and positive symptoms as rated by the Scale for the Assessment of Positive Symptoms (SAPS) were extracted. Variability among symptom-pair correlations across studies was assessed using tests of homogeneity. For symptom-pair correlations which were not found to be homogeneous, the association of average duration of illness with the symptom-pair correlations were examined.ResultsThere was considerable variability in symptom-pair correlations across studies. Part of this variability was explainable by variations in average duration of illness. Longer duration of illness was associated with lower negative–negative symptom-pair correlations and higher negative–positive symptom-pair correlations.ConclusionsThe findings suggest that the structure of symptoms in schizophrenia evolves over time, following a consistent pattern. In the early stages of illness, negative and positive symptoms form cohesive dimensions. With time, these dimensions become less cohesive and the boundaries between them, less clear.