Association between ACE gene I/D polymorphism and knee osteoarthritis in a Chinese population
Association between ACE gene I/D polymorphism and knee osteoarthritis in a Chinese population
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DOI：
10.1042/bsr20181713
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发表时间：
2019-02-28
影响因子：
4
通讯作者：
Qiu, Binsong
中科院分区：
文献类型：
--
作者：
Chen, Genjun;Hu, Shengping;Qiu, Binsong
骨关节炎（OA）是一种退行性关节疾病，其特征是关节破坏，伴有软骨损失和偶尔的关节完整性严重紊乱。近年来，一些研究报道了血管紧张素转换酶（ACE）基因插入/缺失（I/D）多态性与膝关节OA之间的关联。然而，结果是相互矛盾的。为了确定ACE基因I/D多态性与膝关节OA的关系，我们对282例膝关节OA患者和316例对照者进行了一项以医院为基础的病例对照研究，以探讨ACE基因I/D多态性与中国汉族人群膝关节OA易感性的关系。本研究发现ACE基因I/D多态性的DD基因型或D等位基因携带者增加了膝关节OA的风险。对性别、年龄和体重指数（BMI）的分层分析显示，女性、>= 55岁和BMI异常组之间存在显著相关性。此外，本研究还对ACE基因I/D多态性与OA的一些临床特征进行了分析，发现I/D多态性DD基因型与关节痛相关。此外，我们与本研究一起进行了单核苷酸多态性（SNP）与膝关节OA风险之间的荟萃分析。这项荟萃分析发现ACE基因I/D多态性与OA风险增加相关。在这项荟萃分析中，种族分层分析表明，在亚洲人和白人中，I/D多态性增加了膝关节OA的风险。总之，本病例对照研究和荟萃分析表明，ACE基因I/D多态性与膝关节OA的风险增加有关。
Osteoarthritis (OA) is a degenerative joint disease characterized by joint destruction with cartilage loss and occasional gross derangement of joint integrity. In recent years, several studies have reported the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and knee OA. However, the results were conflicting. To determine the association between ACE gene I/D polymorphism and knee OA, we conducted a hospital-based case-control study with 282 knee OA cases and 316 controls to investigate the association between ACE gene I/D polymorphism and knee OA susceptibility in a Chinese Han population. The present study found that DD genotype or D allele carriers of ACE gene I/D polymorphism increased the risk of knee OA. Stratification analyses of sex, age, and body mass index (BMI) showed significant associations amongst the groups of females, >= 55 years, and abnormal BMI. In addition, the present study made analysis between ACE I/D polymorphism and some clinical features of OA, and found DD genotype of I/D polymorphism was associated with arthralgia. Furthermore, we undertook a meta-analysis together with the present study between this single nucleotide polymorphism (SNP) and knee OA risk. This meta-analysis found that ACE gene I/D polymorphism was associated with increased risk for OA. Stratification analysis of ethnicity in this meta-analysis indicated that I/D polymorphism increased the risk of knee OA amongst the Asians and Caucasians. In conclusion, this case-control study and meta-analysis suggest that ACE gene I/D polymorphism is associated with increased risk for knee OA.