Zn impacts Cu coordination to amyloid-β, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity
Zn impacts Cu coordination to amyloid-β, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity
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DOI：
10.1039/c2cc38236a
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Hureau, Christelle
中科院分区：
文献类型：
--
作者：
Alies, Bruno;Sasaki, Isabelle;Hureau, Christelle
已使用XANES、EPR和NMR光谱研究了Zn-II和Cu-I或Cu-II与淀粉样β肽的组合配位。虽然ZnII确实改变了Cu-II与A β的结合，但这对（A β）Cu诱导的ROS产生和相关的细胞毒性没有影响。
Combined coordination of Zn-II and Cu-I or Cu-II to the amyloid-beta peptide has been investigated using XANES, EPR and NMR spectroscopies. While ZnII does alter Cu-II binding to A beta, this has no effect on (A beta)Cu induced ROS production and associated cell toxicity.