Heritability estimates for the constitutional levels of the collectins mannan-binding lectin and lung surfactant protein D. A study of unselected like-sexed mono- and dizygotic twins at the age of 6-9 years
Heritability estimates for the constitutional levels of the collectins mannan-binding lectin and lung surfactant protein D. A study of unselected like-sexed mono- and dizygotic twins at the age of 6-9 years
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DOI：
10.1046/j.1365-2567.2002.01436.x
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发表时间：
2002-07-01
期刊：
影响因子：
6.4
通讯作者：
Holmskov, U
中科院分区：
文献类型：
--
作者：
Husby, S;Herskind, AM;Holmskov, U
凝集素甘露聚糖结合凝集素（MBL）和肺表面活性蛋白D（SP-D）在天然免疫中起重要作用。MBL的结构和启动子变体一样威尔斯是已知的，不同的等位基因与血清中的低MBL浓度相关，并易患感染性疾病。SP-D的结构变异也是已知的，但这些变异与疾病状态无关。本研究的目的是提供儿童MBL和SP-D体质水平的遗传度估计。对26对6-9岁同卵双生子和36对异卵双生子进行了研究。组内相关性显着较高，在MZ比DZ双胞胎，表明大量的MBL和SP-D水平的遗传影响。生物计量学模型拟合结果表明，在非加性遗传因素和非共享环境因素的影响下，MBL的遗传力为0.96（95%CI 0.92-0.97），SP-D的遗传力为0.91（95%CI 0.83-0.95）。这些数据表明，MBL和SP-D的血清水平在数量上具有很强的遗传依赖性。
The collectins mannan-binding lectin (MBL) and lung surfactant protein D (SP-D) play a significant role in innate immunity. Structural as wells as promoter variants are known for MBL and different alleles correlate with low MBL concentrations in serum and predispose to infectious diseases. Structural variants are also known for SP-D but these have not been linked to disease states. The aim of the present study was to provide heritability estimates for the constitutional levels of MBL and SP-D in children. A population of 26 monozygotic (MZ) and 36 dizygotic (DZ) like-sexed twin pairs aged 6-9 years was studied. Intraclass correlations were significantly higher in MZ than in DZ twins, indicating substantial genetic influence on both MBL and SP-D levels. Biometric model fitting showed that the estimated heritability was 0.96 (95% CI 0.92-0.97) for MBL with the presence of non-additive genetic factors and non-shared environmental factors and 0.91 (95% CI 0.83-0.95) for SP-D with additive genetic and non-shared environmental factors. The data indicate quantitatively very strong genetic dependence for the serum levels of both MBL and SP-D.