Gordona terrae central nervous system infection in an immunocompetent patient
Gordona terrae central nervous system infection in an immunocompetent patient
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免疫功能正常患者的戈多纳中枢神经系统感染
DOI：
10.1128/jcm.35.2.379-382.1997
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发表时间：
1997
影响因子：
9.4
通讯作者：
D. Raoult
中科院分区：
文献类型：
--
作者：
M. Drancourt;J. Pelletier;A. Chérif;D. Raoult
细菌属Gordona包括7种含有霉菌酸的放线菌，这些放线菌来自环境来源，很少来自临床样本。它们与两名免疫受损患者的原发肺部疾病、医院伤口感染和中枢神经系统感染有关。我们从一位免疫功能正常的脑膜炎和多发性脑脓肿患者的脑脊液样本中分离出Gordona terrae，并在脓肿中检测到Gordona terrae DNA。在甲氧苄氨嘧啶-磺胺甲恶唑延长治疗后的4年随访中，结果良好。通过对16S rRNA基因序列的分析，证实了该菌株的表型鉴定，与G.terrae参考菌株的表型鉴定具有100%的同源性。医生和临床微生物学家必须意识到戈多纳感染不仅发生在免疫功能低下的患者中，而且发生在所有患者中。利用分子技术可以实现对戈多纳物种的准确鉴定。
The bacterial genus Gordona includes seven species of mycolic acid-containing actinomycetes which are cultured from environmental sources and rarely from clinical samples. They have been implicated in primary pulmonary diseases, nosocomial wound infections, and central nervous system infections in two immunocompromised patients. We isolated Gordona terrae from the cerebrospinal fluid sample of an immunocompetent patient with meningitis and multiple brain abscesses and detected Gordona terrae DNA in the abscesses. The outcome was good at the 4-year follow-up, after prolonged treatment with trimethoprim-sulfamethoxazole. Phenotypic identification of this isolate was confirmed by analysis of the 16S rRNA gene sequence, which shared 100% homology with that of G. terrae reference strains. Physicians and clinical microbiologists must be aware of the occurrence of Gordona species infection not only among immunocompromised patients but among all patients. Accurate identification of Gordona species may be accomplished by molecular techniques.