Epigallocatechin 3-gallate: From green tea to cancer therapeutics
Epigallocatechin 3-gallate: From green tea to cancer therapeutics
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DOI：
10.1016/j.foodchem.2022.132135
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发表时间：
2022-01-18
期刊：
影响因子：
8.8
通讯作者：
Hassan, Md Imtaiyaz
中科院分区：
文献类型：
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作者：
Alam, Manzar;Ali, Sabeeha;Hassan, Md Imtaiyaz
表没食子儿茶素没食子酸酯（Epigallocatechin 3-gallate，EGCG）具有多种生物学功能，包括抗癌和抗肿瘤作用。表没食子儿茶素没食子酸酯是一种丰富的多酚类成分，来源于绿色茶提取物，在对抗多种癌症方面表现出多种生物活性。本文综述了表没食子儿茶素没食子酸酯的药理学特征及其在癌症和其他代谢性疾病中的治疗意义。它调节许多信号通路，调节细胞的不期望的生存和增殖，从而赋予强大的肿瘤化学预防和治疗作用。EGCG通过内在途径启动细胞死亡，并在几种癌症中引起EGFR、STAT 3和ERK途径的抑制。EGCG改变并抑制ERK 1/2、NF-κ B和Akt介导的信号传导，改变Bcl-2家族蛋白的比例并激活肿瘤细胞中的半胱天冬酶。本文综述了表没食子儿茶素没食子酸酯的抗癌、抗氧化、抗炎、抗血管生成和凋亡作用。我们进一步强调了EGCG在不同类型癌症中的潜力，强调了临床试验配方，进一步提高了我们对癌症和炎症性疾病治疗管理的理解。
Epigallocatechin 3-gallate (EGCG) possesses various biological functions, including anti-cancer and antiinflammatory properties. EGCG is an abundant polyphenolic component originating from green tea extract that has exhibited versatile bioactivities in combating several cancers. This review highlights the pharmacological features of EGCG and its therapeutic implications in cancer and other metabolic diseases. It modulates numerous signaling pathways, regulating cells' undesired survival and proliferation, thus imparting strong tumor chemopreventive and therapeutic effects. EGCG initiates cell death through the intrinsic pathway and causes inhibition of EGFR, STAT3, and ERK pathways in several cancers. EGCG alters and inhibits ERK1/2, NF-kappa B, and Akt-mediated signaling, altering the Bcl-2 family proteins ratio and activating caspases in tumor cells. This review focuses on anti-cancer, anti-oxidant, anti-inflammatory, anti-angiogenesis, and apoptotic effects of EGCG. We further highlighted the potential of EGCG in different types of cancer, emphasizing clinical trials formulations that further improve our understanding of the therapeutic management of cancer and inflammatory diseases.