Corneal Epithelial Thickness Map in Long-Term Soft Contact Lenses Wearers
Corneal Epithelial Thickness Map in Long-Term Soft Contact Lenses Wearers
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长期软性隐形眼镜佩戴者的角膜上皮厚度图
DOI：
10.1097/opx.0000000000000410
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发表时间：
2014-12-01
影响因子：
1.4
通讯作者：
Xu, Jianjiang
中科院分区：
文献类型：
--
作者：
Hong, Jiaxu;Qian, Tingting;Xu, Jianjiang
目的.采用傅立叶域光学相干断层扫描（OCT）技术对长期配戴软性接触透镜（SCL）的患者进行角膜上皮厚度的活体测量。这是一项横断面观察性研究。选取40名从未配戴过SCL的正常受试者和40名配戴超过2年的SCL配戴者的40只眼。角膜上皮在整个角膜地形图成像使用一种新的光学相干断层扫描系统。自动生成上皮厚度图。获得中央2 mm、中央旁2- 5 mm（P1）和中周5- 6 mm（P2）区的上皮厚度。此外，还测量和分析了P1和P2区上皮图谱的变异性，包括最大-最小值（MAX-MIN）、图谱SD和变异系数（CV）。正常眼中央、P1和P2区的平均上皮厚度分别为54.4 +/- 1.1 μ m、53.2 +/- 2.2 μ m和52.3 +/- 2.0 μ m，正常眼分别为49.2 +/- 1.9 μ m、48.8 +/- 2.2 μ m和48.7 +/- 2.8 μ m，戴SCL的眼睛。与正常对照组相比，长期SCL患者眼的三个区域的上皮厚度均明显变薄（p < 0.05）。然而，两组之间P1和P2区的最大-最小值、SD和CV没有差异。在两组中，中央旁区和中周边区的上皮厚度在不同区段之间存在显著差异。长期佩戴SCL的受试者上皮厚度减少。临床医生应注意中央旁和中周边角膜上皮厚度的不均匀性。这种方法可能是有用的检测角膜上皮厚度的变化所造成的长期SCL磨损的早期。
Purpose. To map the corneal epithelial thickness in vivo with Fourier-domain optical coherence tomography in long-term soft contact lens (SCL) wearers.Methods. This is a cross-sectional observational study. Forty eyes from 40 normal subjects who had never worn SCL and 40 eyes from 40 SCL wearers who had worn lenses for more than 2 years were enrolled. Corneal epithelium over the entire cornea was topographically imaged using a novel optical coherence tomography system. An epithelial thickness map was automatically generated. Epithelial thicknesses of the central 2-mm, paracentral 2- to 5-mm(P1), and midperipheral 5- to 6-mm (P2) zones were obtained. In addition, the epithelial map variability in P1 and P2 zones, including maximum - minimum (MAX - MIN), map SD, and coefficient of variation (CV), was measured and analyzed.Results. The average epithelial thickness of the central, P1, and P2 zones was 54.4 +/- 1.1 mu m, 53.2 +/- 2.2 mu m, and 52.3 +/- 2.0 mu m, respectively, in normal eyes and 49.2 +/- 1.9 mu m, 48.8 +/- 2.2 mu m, and 48.7 +/- 2.8 mu m, respectively, in eyes wearing SCL. Compared with normal control subjects, eyes with long-term SCL had significantly thinner epithelial thickness in all three zones (p < 0.05). However, there was no difference in MAX - MIN, SD, and CV of P1 and P2 zones between two groups. In both groups, there was significant difference in the epithelial thickness among different sectors in the paracentral and midperipheral zones.Conclusions. There is a decrease in epithelial thickness in subjects who wear SCL long term. Clinicians should take note of the nonuniformity of the paracentral and midperipheral corneal epithelium thicknesses. This method may be useful for detecting early changes in corneal epithelial thickness caused by long-term SCL wear.