Food and the gut microbiota in inflammatory bowel diseases: a critical connection.
Food and the gut microbiota in inflammatory bowel diseases: a critical connection.
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DOI：
10.1097/mog.0b013e328354586f
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发表时间：
2012-07
影响因子：
2.5
通讯作者：
Wu GD
中科院分区：
文献类型：
--
作者：
Albenberg LG;Lewis JD;Wu GD
炎症性肠病（inflammatory bowel diseases，IBD）是一种慢性胃肠道炎症性疾病，是由遗传易感宿主对环境因素的异常免疫反应引起的。肠道微生物组的组成被认为是IBD的一个关键环境因素，最近的证据表明饮食和肠道细菌之间存在联系。在这篇综述中，我们描述了目前关于饮食对肠道微生物组的影响的证据，以及这可能与IBD的发病机制有关。新型的不依赖于培养的DNA测序技术彻底改变了表征肠道细菌群落的方法。最近的研究表明饮食与人体微生物组组成之间存在联系。由于“生态失调”微生物组的发展被认为与IBD的发病机制有关，因此饮食被认为是一个重要的致病因素。最近的研究强调了饮食对肠道微生物组的影响，为进一步研究饮食，肠道微生物组和IBD发展之间的联系提供了强有力的依据。这些研究可能提供有关疾病发病机制的新信息，并为IBD患者确定新的治疗方案。
The inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the gastrointestinal tract apparently due to an abnormal immune response to environmental factors in genetically susceptible hosts. The composition of the gut microbiome is thought to be a critical environmental factor in IBD, and recent evidence suggests a connection between diet and the intestinal bacteria. In this review, we describe the current evidence regarding the impact of diet on the gut microbiome and how this may be relevant to the pathogenesis of IBD. Novel culture-independent DNA sequencing technology has revolutionized the approach to the characterization of intestinal bacterial communities. Recent studies have demonstrated an association between the diet and the composition of the human microbiome. Because the development of a “dysbiotic” microbiome is thought to be involved in the pathogenesis of IBD, diet is being investigated as an important etiologic factor. The recent studies highlighting the impact of diet on the gut microbiome provide a strong rationale for further investigation of the link between diet, the gut microbiome, and the development of IBD. Such studies may provide novel information about disease pathogenesis as well as identify new therapeutic alternatives for patients suffering from IBD.