A unified nomenclature for peroxisome biogenesis factors.
A unified nomenclature for peroxisome biogenesis factors.
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DOI：
10.1083/jcb.135.1.1
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发表时间：
1996-10
期刊：
影响因子：
--
通讯作者：
Veenhuis M
中科院分区：
文献类型：
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作者：
Distel B;Erdmann R;Gould SJ;Blobel G;Crane DI;Cregg JM;Dodt G;Fujiki Y;Goodman JM;Just WW;Kiel JA;Kunau WH;Lazarow PB;Mannaerts GP;Moser HW;Osumi T;Rachubinski RA;Roscher A;Subramani S;Tabak HF;Tsukamoto T;Valle D;van der Klei I;van Veldhoven PP;Veenhuis M
近10年来，过氧化物酶体生物合成研究取得了重大进展。这一进展的一个关键是在各种各样的实验生物中使用遗传方法（4，8，11，15，18，21，26，35，38，47，48）。迄今为止，这些系统已被用来确定过氧化物酶体生物合成所需的13种蛋白质，其中三种也已被证明是致命的过氧化物酶体生物合成障碍的缺陷。然而，实验系统的多样性也导致过氧化物酶体组装基因和蛋白质的名称繁多。这些包括PAS、PAF、PER、PAY、PEB和PMP的缩写，并且跨越更大的编号系统阵列。应《细胞生物学杂志》编辑的要求，为了所有相关人员的利益，我们考虑了基因和蛋白质名称、编号系统以及要包含的基因和蛋白质类型的可能定义的几种选择。我们在这里提出一个统一的蛋白质和基因命名过氧化物酶体生物合成因子。参与过氧化物酶体（微体）生物发生的蛋白质（包括过氧化物酶体基质蛋白输入、膜生物发生、过氧化物酶体增殖和过氧化物酶体增殖）
OR the past 10 years, there has been substantial progress in the field of peroxisome biogenesis. One key to this progress has been the use of genetic approaches in a wide variety of experimental organisms (4, 8, 11, 15, 18, 21, 26, 35, 38, 47, 48). To date, these systems have been used to identify thirteen proteins required for peroxisome biogenesis, three of which have also been shown to be defective in the lethal peroxisome biogenesis disorders. However, the diversity of experimental systems has also led to a profusion of names for peroxisome assembly genes and proteins. These include the acronyms PAS, PAF, PER, PAY, PEB, and PMP and span an even greater array of numbering systems. At the request of the Editors of The Journal of Cell Biology and for the benefit of all concerned, we considered several options for gene and protein names, numbering systems, and possible definitions for the types of genes and protein to be included. We propose here a unified protein and gene nomenclature for peroxisome biogenesis factors. Proteins involved in peroxisome (microbody) biogenesis (inclusive of peroxisomal matrix protein import, membrane biogenesis, peroxisome proliferation, and peroxi-