Development of extensive brain lesions following fingolimod (FTY720) treatment in a patient with neuromyelitis optica spectrum disorder
Development of extensive brain lesions following fingolimod (FTY720) treatment in a patient with neuromyelitis optica spectrum disorder
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DOI：
10.1177/1352458511431973
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发表时间：
2012-01-01
影响因子：
5.8
通讯作者：
Lee, Kwang Ho
中科院分区：
文献类型：
--
作者：
Min, Ju-Hong;Kim, Byoung Joon;Lee, Kwang Ho
我们报告了一例在TRANSFORMS研究中芬戈莫德（FTY 720）治疗期间发生广泛脑损伤的患者。他最初的诊断是多发性硬化，但在检测到脑病抗水通道蛋白4抗体（抗AQP4 Ab）后，改变为视神经肌萎缩谱系障碍。芬戈莫德治疗后，患者出现双侧广泛脑损伤。脑部MRI显示病变主要累及右侧额叶和顶叶，伴血管源性水肿和强化。他有残留的脑软化，在芬戈莫德停药后3年内类固醇治疗没有复发。
We report the case of a patient who developed extensive brain lesions during fingolimod (FTY720) treatment in the TRANSFORMS study. His initial diagnosis was multiple sclerosis, but after encephalopathy anti-aquaporin4 antibody (anti-AQP4 Ab) was detected, it was changed to neuromyelitis optica spectrum disorder. After treatment with fingolimod, he developed bilateral extensive brain lesions. The brain MRI showed lesions predominantly involving the right frontal and parietal lobes, with vasogenic edema and enhancement. He had residual encephalomalacia and no recurrence with steroid treatment over 3 years following withdrawal of fingolimod.