Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study.
Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study.
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DOI：
10.1038/s41598-021-90026-8
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发表时间：
2021-05-18
影响因子：
4.6
通讯作者：
Suzuki H
中科院分区：
文献类型：
--
作者：
Takeuchi Y;Akashi Y;Kato D;Kuwahara M;Muramatsu S;Ueda A;Notake S;Nakamura K;Ishikawa H;Suzuki H
使用前鼻标本进行抗原检测的临床应用尚未得到很好的评价。我们在PCR中心的免过式检测点进行前瞻性研究，评估前鼻标本抗原检测QuickNavi-COVID19 Ag的诊断效果，比较前鼻采集与鼻咽采集的咳嗽或打喷嚏诱发程度和疼痛程度。该研究共纳入862名参与者，其中91.6%有症状。从症状出现到样本采集的中位持续时间为2.0天。51名参与者鼻咽样本逆转录PCR检测为严重急性呼吸综合征冠状病毒2型阳性，均有症状。与RT-PCR结果相比，使用前鼻标本进行抗原检测的灵敏度为72.5%(95%可信区间[CI] 58.3-84.1%)，特异性为100% （95% CI 99.3-100%）。与鼻咽部收集相比，前鼻收集与明显较低的咳嗽或打喷嚏诱发程度和疼痛严重程度相关（p < 0.001）。使用前鼻样本进行的抗原试验显示，在病程早期有症状的患者中，有中度敏感性，但疼痛较少，咳嗽或打喷嚏较少。
The clinical utility of antigen test using anterior nasal samples has not been well evaluated. We conducted a prospective study in a drive-through testing site located at a PCR center to evaluate the diagnostic performance of the antigen test QuickNavi-COVID19 Ag using anterior nasal samples and to compare the degrees of coughs or sneezes induction and the severity of pain between anterior nasal collection and nasopharyngeal collection. The study included a total of 862 participants, of which 91.6% were symptomatic. The median duration from symptom onset to sample collection was 2.0 days. Fifty-one participants tested positive for severe acute respiratory syndrome coronavirus 2 on reverse transcription PCR (RT-PCR) with nasopharyngeal samples, and all of them were symptomatic. In comparison to the findings of RT-PCR, the antigen test using anterior nasal samples showed 72.5% sensitivity (95% confidence interval [CI] 58.3–84.1%) and 100% specificity (95% CI 99.3–100%). Anterior nasal collection was associated with a significantly lower degree of coughs or sneezes induction and the severity of pain in comparison to nasopharyngeal collection (p < 0.001). The antigen test using anterior nasal samples showed moderate sensitivity in symptomatic patients who were at the early stages of the disease course but was less painful and induced fewer coughs or sneezes.
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DOI：
10.1016/j.jiac.2020.11.021
发表时间：
2021-04
期刊：
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
影响因子：
--
作者：
Aoki K;Nagasawa T;Ishii Y;Yagi S;Okuma S;Kashiwagi K;Maeda T;Miyazaki T;Yoshizawa S;Tateda K
通讯作者：
Tateda K
影响因子：
9.4
作者：
Lee RA;Herigon JC;Benedetti A;Pollock NR;Denkinger CM
通讯作者：
Denkinger CM
使用Lumipulse SARS-COV-2抗原测试：与RT-QPCR进行比较，对1033名患者的1308名鼻咽拭子进行了前瞻性研究。
DOI：
10.1016/j.ijid.2021.02.005
发表时间：
2021-04
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
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作者：
Hirotsu Y;Maejima M;Shibusawa M;Amemiya K;Nagakubo Y;Hosaka K;Sueki H;Hayakawa M;Mochizuki H;Tsutsui T;Kakizaki Y;Miyashita Y;Omata M
通讯作者：
Omata M
影响因子：
3.7
作者：
Zasada, Aleksandra Anna;Zacharczuk, Katarzyna;Malinowska, Elzbieta
通讯作者：
Malinowska, Elzbieta
DOI：
10.1016/s1473-3099(21)00146-8
发表时间：
2021-09
期刊：
The Lancet. Infectious diseases
影响因子：
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作者：
Tsang NNY;So HC;Ng KY;Cowling BJ;Leung GM;Ip DKM
通讯作者：
Ip DKM