What about physical contacts between epidermal keratinocytes and sensory neurons?
What about physical contacts between epidermal keratinocytes and sensory neurons?
复制标题
表皮角质形成细胞和感觉神经元之间的物理接触怎么样？
作者：
M. Talagas;N. Lebonvallet;R. Leschiera;P. Marcorelles;L. Miséry
最近的研究表明，角质形成细胞密切参与感觉传导，因此，表皮内游离神经末梢不是唯一的疼痛传感器。这一发现意味着角质形成细胞与感觉神经元之间存在密切的传入通讯。尽管角质形成细胞和表皮内自由神经末梢之间通过可溶性介质的相互作用已得到充分证实，但人们很少关注角质形成细胞和表皮内自由神经末梢之间的物理接触。本综述建议考虑这些接触的超微结构和功能知识，在人类皮肤活检和角质形成细胞-感觉神经元共培养物中推测突触接触的可能存在。
Recent studies have demonstrated that keratinocytes closely participate in sensory transduction, and therefore, intra‐epidermal free nerve endings are not exclusive transducers of pain. This discovery implies the existence of close afferent communication from keratinocytes to sensory neurons. Although reciprocal interactions between keratinocytes and intra‐epidermal free nerve endings via soluble mediators are well established, little attention has been paid to physical contacts between keratinocytes and intra‐epidermal free nerve endings. This review proposes to consider the ultrastructural and functional knowledge of these contacts, in both human skin biopsies and keratinocyte‐sensory neuron cocultures to speculate on the possible existence of synaptic contacts.
影响因子：
2.7
作者：
Morrison, Kristin M.;Miesegaes, George R.;Lumpkin, Ellen A.;Maricich, Stephen M.
通讯作者：
Maricich, Stephen M.