Transient analysis of streptavidin-biotin complex detection using an IGZO thin film transistor-based biosensor integrated with a microfluidic channel
Transient analysis of streptavidin-biotin complex detection using an IGZO thin film transistor-based biosensor integrated with a microfluidic channel
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DOI：
10.1016/j.snb.2017.01.050
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发表时间：
2017-06-01
影响因子：
8.4
通讯作者：
Huang, Jian-Jang
中科院分区：
文献类型：
--
作者：
Chen, Ting-Yang;Yang, Tsung-Han;Huang, Jian-Jang
我们展示了一个集成的生物传感器与薄膜晶体管记录生物分子携带的电荷和微流体通道检测目标溶液的扩散特性。以链霉亲和素和生物素为例，传感器能够通过监测晶体管电流的瞬态响应来检测链霉亲和素-生物素复合物的结合相互作用。我们的方法可以应用于蛋白质相互作用的检测领域。(C)2017爱思唯尔B. V.保留所有权利。
We demonstrated an integrated biosensor with a thin film transistor for recording electrical charges carried by bio-molecules and a microfluidic channel for detecting diffusion properties of the target solution. Using streptavidin and biotin as examples, the sensor is able to detect the binding interaction of streptavidin-biotin complexes by monitoring the transient responses of the transistor current. Our approach can be applied to the field of detection of protein-protein interactions. (C) 2017 Elsevier B.V. All rights reserved.