CHOROIDAL THICKNESS OF CENTRAL SEROUS CHORIORETINOPATHY SECONDARY TO CORTICOSTEROID USE
CHOROIDAL THICKNESS OF CENTRAL SEROUS CHORIORETINOPATHY SECONDARY TO CORTICOSTEROID USE
复制标题
DOI：
10.1097/iae.0000000000001380
复制
发表时间：
2017-08-01
影响因子：
3.3
通讯作者：
Nakamura, Makoto
中科院分区：
文献类型：
--
作者：
Honda, Shigeru;Miki, Akiko;Nakamura, Makoto
目的：中心性浆液性脉络膜视网膜病变（CSC）是一种常见的脉络膜疾病，经常影响年轻人的视力。尽管与 CSC 相关的分子机制仍不清楚，但类固醇激素的使用与 CSC 之间的相关性已被怀疑。我们调查了继发于皮质类固醇使用的CSC的脉络膜状态。方法：对25例连续的继发于皮质类固醇使用的急性CSC病例的25只眼的记录进行回顾性分析。通过光学相干断层扫描测量中央脉络膜厚度。根据吲哚菁绿血管造影结果评估脉络膜血管扩张和脉络膜血管渗透性过高。将继发性CSC相关参数与25例急性特发性CSC的25只眼进行比较。结果：继发性CSC的平均中央脉络膜厚度为294.8±95.0mm，明显薄于特发性CSC的中央脉络膜厚度（409.4±124.7mm，P=0.00064）。继发性 CSC (52%) 和特发性 CSC (64%) 之间表现出脉络膜血管扩张的病例比例没有显着差异。继发性CSC（62%）出现脉络膜血管通透性过高的病例比例（62%）显着小于特发性CSC（92%）（P = 0.028）。结论：使用皮质类固醇后继发性CSC急性期的脉络膜状态可能与特发性CSC不同，这表明CSC存在复杂的机制。
Purpose: Central serous chorioretinopathy (CSC) is a common choroidal disorder which often affects the vision of young adults. Although the molecular mechanisms associated with CSC remain unknown, correlations between steroid hormone use and CSC have been suspected. We investigated the choroidal status of CSC secondary to corticosteroid use.Methods: The records of 25 eyes of 25 consecutive acute CSC cases secondary to corticosteroid use were reviewed retrospectively. Central choroidal thickness was measured by optical coherent tomography. Choroidal vessel dilation and choroidal vascular hyperpermeability were evaluated based on indocyanine green angiography findings. The parameters related to secondary CSC were compared with those of 25 eyes of 25 cases with acute idiopathic CSC.Results: The mean central choroidal thickness of secondary CSC was 294.8 +/- 95.0 mm, which was significantly thinner than that of idiopathic CSC (409.4 +/- 124.7 mm, P = 0.00064). The proportion of the cases exhibiting choroidal vessel dilation was not significantly different between secondary CSC (52%) and idiopathic CSC (64%). The proportion of cases showing choroidal vascular hyperpermeability was significantly smaller in secondary CSC (62%) than idiopathic CSC (92%) (P = 0.028).Conclusion: The choroidal status in the acute phase of secondary CSC after corticosteroid use might be different from that of idiopathic CSC, which suggests a complex mechanism for CSC.